Cited 14 times in
Resveratrol Inhibits Phenotype Modulation by Platelet Derived Growth Factor-bb in Rat Aortic Smooth Muscle Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구민아 | - |
dc.contributor.author | 권병주 | - |
dc.contributor.author | 김민성 | - |
dc.contributor.author | 류경은 | - |
dc.contributor.author | 박종철 | - |
dc.contributor.author | 서혁진 | - |
dc.contributor.author | 이미희 | - |
dc.date.accessioned | 2015-01-06T16:32:32Z | - |
dc.date.available | 2015-01-06T16:32:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1942-0900 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98300 | - |
dc.description.abstract | Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of platelet derived growth factor-bb (PDGF-bb) in rat aortic vascular smooth muscle cells (RAOSMCs). Treatment of RAOSMCs with resveratrol showed dose-dependent inhibition of PDGF-bb-stimulated proliferation. Resveratrol treatment inhibited this phenotype change and disassembly of actin filaments and maintained the expression of contractile phenotype-related proteins such as calponin and smooth muscle actin-alpha in comparison with only PDGF-bb stimulated RAOSMC. Although PDGF stimulation elicited strong and detectable Akt and mTOR phosphorylations lasting for several hours, Akt activation was much weaker when PDGF was used with resveratrol. In contrast, resveratrol only slightly inhibited phosphorylations of 42/44 MAPK and p38 MAPK. In conclusion, RAOSMC dedifferentiation, phenotype, and proliferation rate were inhibited by resveratrol via interruption of the balance of Akt, 42/44MAPK, and p38MAPK pathway activation stimulated by PDGF-bb. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Actin Cytoskeleton/drug effects | - |
dc.subject.MESH | Actin Cytoskeleton/metabolism | - |
dc.subject.MESH | Actins/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aorta/cytology* | - |
dc.subject.MESH | Cell Dedifferentiation/drug effects | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Cell Shape/drug effects | - |
dc.subject.MESH | Myocytes, Smooth Muscle/cytology* | - |
dc.subject.MESH | Phenotype | - |
dc.subject.MESH | Proto-Oncogene Proteins c-sis/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Stilbenes/pharmacology* | - |
dc.title | Resveratrol Inhibits Phenotype Modulation by Platelet Derived Growth Factor-bb in Rat Aortic Smooth Muscle Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학) | - |
dc.contributor.googleauthor | Mi Hee Lee | - |
dc.contributor.googleauthor | Byeong-Ju Kwon | - |
dc.contributor.googleauthor | Hyok Jin Seo | - |
dc.contributor.googleauthor | Kyeong Eun Yoo | - |
dc.contributor.googleauthor | Min Sung Kim | - |
dc.contributor.googleauthor | Min-Ah Koo | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.identifier.doi | 10.1155/2014/572430 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00190 | - |
dc.contributor.localId | A00218 | - |
dc.contributor.localId | A01319 | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A01922 | - |
dc.contributor.localId | A02777 | - |
dc.contributor.localId | A00460 | - |
dc.relation.journalcode | J02455 | - |
dc.identifier.eissn | 1942-0994 | - |
dc.identifier.pmid | 24738020 | - |
dc.contributor.alternativeName | Koo, Min Ah | - |
dc.contributor.alternativeName | Kwon, Byeong Ju | - |
dc.contributor.alternativeName | Kim, Min Sung | - |
dc.contributor.alternativeName | You, Kyung Eun | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Seo, Hyok Jin | - |
dc.contributor.alternativeName | Lee, Mi Hee | - |
dc.contributor.affiliatedAuthor | Koo, Min Ah | - |
dc.contributor.affiliatedAuthor | Kwon, Byeong Ju | - |
dc.contributor.affiliatedAuthor | You, Kyung Eun | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Seo, Hyok Jin | - |
dc.contributor.affiliatedAuthor | Lee, Mi Hee | - |
dc.contributor.affiliatedAuthor | Kim, Min Sung | - |
dc.citation.volume | 2014 | - |
dc.citation.startPage | 572430 | - |
dc.identifier.bibliographicCitation | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Vol.2014 : 572430, 2014 | - |
dc.identifier.rimsid | 51824 | - |
dc.type.rims | ART | - |
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