Cited 41 times in
Chronic liver inflammation: Clinical implications beyond alcoholic liver disease
DC Field | Value | Language |
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dc.contributor.author | 이용제 | - |
dc.contributor.author | 이혜리 | - |
dc.date.accessioned | 2015-01-06T16:29:15Z | - |
dc.date.available | 2015-01-06T16:29:15Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98197 | - |
dc.description.abstract | Chronic alcohol exposure can lead to alcoholic liver disease, including hepatitis, cirrhosis and hepatocellular carcinoma, and chronic inflammation can simultaneously cause systemic medical illness. Recent evidence suggests that alcoholic liver disease is a predictor for liver-related diseases, cardiovascular disease, immunologic disease, and bone disease. Chronic inflammation in alcoholic liver disease is mediated by a direct inflammatory cascade from the alcohol detoxification process and an indirect inflammatory cascade in response to gut microflora-derived lipopolysaccharides (LPS). The pathophysiology of alcoholic liver disease and its related systemic illness is characterized by oxidative stress, activation of the immune cascade, and gut-liver interactions. Integrative therapeutic strategies for alcoholic liver disease include abstaining from alcohol consumption; general anti-inflammatories such as glucocorticoid, pentoxifylline, and tumour necrosis factor-α antagonist; antioxidants such as N- acetylcysteine; gut microflora and LPS modulators such as rifaximin and/or probiotics. This review focuses on the impact of chronic liver inflammation on systemic health problems and several potential therapeutic targets. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2168~2175 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alcohol Drinking/adverse effects* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Bacterial Agents/therapeutic use | - |
dc.subject.MESH | Anti-Inflammatory Agents/therapeutic use | - |
dc.subject.MESH | Antioxidants/therapeutic use | - |
dc.subject.MESH | Bone Diseases/diagnosis | - |
dc.subject.MESH | Bone Diseases/etiology* | - |
dc.subject.MESH | Bone Diseases/metabolism | - |
dc.subject.MESH | Bone Diseases/microbiology | - |
dc.subject.MESH | Bone Diseases/physiopathology | - |
dc.subject.MESH | Bone Diseases/therapy | - |
dc.subject.MESH | Cardiovascular Diseases/diagnosis | - |
dc.subject.MESH | Cardiovascular Diseases/etiology* | - |
dc.subject.MESH | Cardiovascular Diseases/metabolism | - |
dc.subject.MESH | Cardiovascular Diseases/microbiology | - |
dc.subject.MESH | Cardiovascular Diseases/physiopathology | - |
dc.subject.MESH | Cardiovascular Diseases/therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immune System Diseases/diagnosis | - |
dc.subject.MESH | Immune System Diseases/etiology* | - |
dc.subject.MESH | Immune System Diseases/metabolism | - |
dc.subject.MESH | Immune System Diseases/microbiology | - |
dc.subject.MESH | Immune System Diseases/physiopathology | - |
dc.subject.MESH | Immune System Diseases/therapy | - |
dc.subject.MESH | Liver Diseases, Alcoholic/complications* | - |
dc.subject.MESH | Liver Diseases, Alcoholic/diagnosis | - |
dc.subject.MESH | Liver Diseases, Alcoholic/metabolism | - |
dc.subject.MESH | Liver Diseases, Alcoholic/microbiology | - |
dc.subject.MESH | Liver Diseases, Alcoholic/physiopathology | - |
dc.subject.MESH | Liver Diseases, Alcoholic/therapy | - |
dc.subject.MESH | Probiotics/therapeutic use | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Chronic liver inflammation: Clinical implications beyond alcoholic liver disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Byoung-Jin Park | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Hye-Ree Lee | - |
dc.identifier.doi | 10.3748/wjg.v20.i9.2168 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03310 | - |
dc.relation.journalcode | J02795 | - |
dc.identifier.eissn | 2219-2840 | - |
dc.identifier.pmid | 24605015 | - |
dc.subject.keyword | Alcoholic liver disease | - |
dc.subject.keyword | Bone disease | - |
dc.subject.keyword | Cardiovascular disease | - |
dc.subject.keyword | Immunologic disease | - |
dc.subject.keyword | Oxidative stress | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.alternativeName | Lee, Hye Ree | - |
dc.contributor.affiliatedAuthor | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | Lee, Hye Ree | - |
dc.citation.volume | 20 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2168 | - |
dc.citation.endPage | 2175 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, Vol.20(9) : 2168-2175, 2014 | - |
dc.identifier.rimsid | 50710 | - |
dc.type.rims | ART | - |
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