Cited 33 times in
Expression of Stress-Induced Phosphoprotein1 (STIP1) is Associated with Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 신하연 | - |
dc.contributor.author | 조한별 | - |
dc.date.accessioned | 2015-01-06T16:28:07Z | - |
dc.date.available | 2015-01-06T16:28:07Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1045-2257 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98161 | - |
dc.description.abstract | Stress-induced phosphoprotein1 (STIP1) is a candidate biomarker in epithelial ovarian cancer (EOC). In this study, we investigated in detail the expression of STIP1, as well as its functions, in EOC. STIP1 expression was assessed by immunohistochemistry (IHC) and the results were compared with clinicopathologic factors, including survival data. The effects of STIP1 gene silencing via small interfering RNA (siRNA) were examined in EOC cells and a xenograft model. The expression of STIP1 protein in EOC was significantly higher than in the other study groups (P < 0.001), and this increase of expression was significantly associated with tumor stage (P = 0.005), tumor grade (P = 0.029), and lymph node metastasis (P = 0.020). In multivariate analysis, overall survival in EOC was significantly shorter in cases with high STIP1 expression (HR = 2.78 [1.01–7.63], P = 0.047). STIP1 silencing in EOC cells resulted in inhibition of cell proliferation and invasion. In addition, in vivo experiments using STIP1 siRNA clearly showed a strong inhibition of tumor growth and a modulation of expression of prosurvival and apoptotic genes, further suggesting that STIP1 silencing can prevent cell proliferation and invasion. In conclusion, increased STIP1 expression is associated with poor survival outcome in EOC, and STIP1 may represent a useful therapeutic target in EOC patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 277~288 | - |
dc.relation.isPartOf | GENES CHROMOSOMES & CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heat-Shock Proteins/genetics* | - |
dc.subject.MESH | Heat-Shock Proteins/metabolism | - |
dc.subject.MESH | Heterografts | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inhibitor of Differentiation Proteins/genetics | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Proteins/genetics | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/diagnosis* | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/genetics* | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/metabolism | - |
dc.subject.MESH | Ovarian Neoplasms/diagnosis* | - |
dc.subject.MESH | Ovarian Neoplasms/genetics* | - |
dc.subject.MESH | Ovarian Neoplasms/metabolism | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Smad1 Protein/metabolism | - |
dc.subject.MESH | Smad5 Protein/metabolism | - |
dc.title | Expression of Stress-Induced Phosphoprotein1 (STIP1) is Associated with Tumor Progression and Poor Prognosis in Epithelial Ovarian Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Ha-Yeon Shin | - |
dc.contributor.googleauthor | Eun Joo Chung | - |
dc.contributor.googleauthor | Haruhisa Kitano | - |
dc.contributor.googleauthor | Jae Hyon Park | - |
dc.contributor.googleauthor | Lucienne Park | - |
dc.contributor.googleauthor | Joon-Yong Chung | - |
dc.contributor.googleauthor | Stephen M. Hewitt | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.identifier.doi | 10.1002/gcc.22136 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A02169 | - |
dc.contributor.localId | A03921 | - |
dc.relation.journalcode | J00930 | - |
dc.identifier.eissn | 1098-2264 | - |
dc.identifier.pmid | 24488757 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/gcc.22136/abstract | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Shin, Ha Yeon | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Shin, Ha Yeon | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 53 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 277 | - |
dc.citation.endPage | 288 | - |
dc.identifier.bibliographicCitation | GENES CHROMOSOMES & CANCER, Vol.53(4) : 277-288, 2014 | - |
dc.identifier.rimsid | 50687 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.