Cited 9 times in
Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권인규 | - |
dc.contributor.author | 노성훈 | - |
dc.contributor.author | 안지영 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 조인 | - |
dc.contributor.author | 최윤영 | - |
dc.contributor.author | 형우진 | - |
dc.date.accessioned | 2015-01-06T16:27:15Z | - |
dc.date.available | 2015-01-06T16:27:15Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0748-7983 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98134 | - |
dc.description.abstract | AIMS: We carried out a large scale study to identify the risk factors for double primary malignancy (DPM) development in gastric cancer patients and to evaluate the clinical implications for these patients. METHODS: A total of 2593 patients who underwent gastrectomy for primary gastric cancer from January 2005 to November 2010 were reviewed with regard to DPM. We compared the clinicopathological characteristics, risk factors for developing DPM, and prognosis between the DPM+ group and the DPM- group. RESULTS: Of the 2593 patients, 152 (5.9%) were diagnosed with DPM. The most common accompanying malignancies were colorectal, lung and thyroid. Multivariate analysis indicated that age (p = 0.016) and MSI status (p = 0.002) were associated with a higher frequency of DPM. 30.3% of patients were diagnosed with DPM within 1 year around perioperative period and 53.3% of patients had DPM detected during 5 years of post-operative follow up periods. Although there was no significant difference in overall survival between the DPM+ and DPM- group, DPM+ patients had a worse prognosis than DPM- patients in stage I gastric cancer. CONCLUSIONS: Gastric cancer patients over the age of 60 or with a MSI-high status had an increased risk for developing DPM. Further, in stage I gastric cancer, the presence of DPM was associated with a worse prognosis. Therefore, careful pre- and postoperative surveillance is especially important in these patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 338~344 | - |
dc.relation.isPartOf | EJSO | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biopsy, Needle | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Colorectal Neoplasms/mortality | - |
dc.subject.MESH | Colorectal Neoplasms/pathology* | - |
dc.subject.MESH | Colorectal Neoplasms/surgery | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lung Neoplasms/mortality | - |
dc.subject.MESH | Lung Neoplasms/pathology* | - |
dc.subject.MESH | Lung Neoplasms/surgery | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness/pathology | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neoplasms, Multiple Primary/mortality | - |
dc.subject.MESH | Neoplasms, Multiple Primary/pathology* | - |
dc.subject.MESH | Neoplasms, Multiple Primary/surgery | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Stomach Neoplasms/mortality | - |
dc.subject.MESH | Stomach Neoplasms/pathology* | - |
dc.subject.MESH | Stomach Neoplasms/surgery | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Thyroid Neoplasms/mortality | - |
dc.subject.MESH | Thyroid Neoplasms/pathology* | - |
dc.subject.MESH | Thyroid Neoplasms/surgery | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | I. Cho | - |
dc.contributor.googleauthor | J.Y. An | - |
dc.contributor.googleauthor | I.G. Kwon | - |
dc.contributor.googleauthor | Y.Y. Choi | - |
dc.contributor.googleauthor | J.H. Cheong | - |
dc.contributor.googleauthor | W.J. Hyung | - |
dc.contributor.googleauthor | S.H. Noh | - |
dc.identifier.doi | 10.1016/j.ejso.2013.10.027 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00243 | - |
dc.contributor.localId | A01281 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A03889 | - |
dc.contributor.localId | A04138 | - |
dc.contributor.localId | A04382 | - |
dc.relation.journalcode | J00847 | - |
dc.identifier.eissn | 1532-2157 | - |
dc.identifier.pmid | 24342136 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0748798313009086 | - |
dc.subject.keyword | Double primary malignancy | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | Microsatellite instability | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Kwon, In Gyu | - |
dc.contributor.alternativeName | Noh, Sung Hoon | - |
dc.contributor.alternativeName | An, Ji Yeong | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Cho, In | - |
dc.contributor.alternativeName | Choi, Yoon Young | - |
dc.contributor.alternativeName | Hyung, Woo Jin | - |
dc.contributor.affiliatedAuthor | Kwon, In Gyu | - |
dc.contributor.affiliatedAuthor | Noh, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Cho, In | - |
dc.contributor.affiliatedAuthor | Choi, Yoon Young | - |
dc.contributor.affiliatedAuthor | Hyung, Woo Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 338 | - |
dc.citation.endPage | 344 | - |
dc.identifier.bibliographicCitation | EJSO, Vol.40(3) : 338-344, 2014 | - |
dc.identifier.rimsid | 50672 | - |
dc.type.rims | ART | - |
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