Cited 38 times in
Postoperative levonorgestrel-releasing intrauterine system versus oral contraceptives after gonadotropin-releasing hormone agonist treatment for preventing endometrioma recurrence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김혜연 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 정지안 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2015-01-06T16:26:04Z | - |
dc.date.available | 2015-01-06T16:26:04Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0001-6349 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98098 | - |
dc.description.abstract | OBJECTIVE: Although the levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in reducing the recurrence of endometriosis-associated pain, its efficacy in preventing endometrioma recurrence is questionable. We compared the efficacy of postoperative use of LNG-IUS with oral contraceptives (OC) for preventing endometrioma recurrence. DESIGN: A retrospective cohort study. SETTING: Medical university hospital. POPULATION: Ninety-nine women with endometriomas. METHODS: A chart review was performed of women of reproductive age who had undergone laparoscopic surgery for endometrioma followed by three cycles of gonadotropin-releasing hormone agonist (leuprolide acetate) treatment. Women were categorized into two groups: a group that had postoperative LNG-IUS placement (n = 42) and a group that received postoperative, cyclic, low-dose, monophasic, OCs (n = 57). Main outcome measures. Endometrioma recurrence was analyzed according to several clinical variables and postoperative treatment modalities. RESULTS: During the follow-up period (median 17 months), recurrent endometriomas were detected in eight women (8.1%). Patients with LNG-IUS had a recurrence rate of 4.8% (2/42), whereas women receiving OC had a recurrence rate of 10.5% (6/57). Cumulative recurrence-free survival assessment revealed that mean disease-free survival times for both groups were similar, but that for LNG-IUS was slightly longer than that for OC, with statistical significance (34.4 ± 1.0 months, 95% confidence interval 32.3–36.5, vs. 33.4 ± 1.3 months, 95% confidence interval 30.8–36.0, p = 0.045). Univariate analysis revealed a hazard ratio of 0.178 (95% confidence interval 0.029–1.075) (p = 0.060) for postoperative LNG-IUS use and endometrioma recurrence. However, for the multivariate regression analysis, only postoperative serum CA 125 levels were significantly associated with endometrioma recurrence (hazard ratio 1.012, p = 0.010).CONCLUSIONS: Postoperative LNG-IUS use seemed to be comparable to the use of cyclic OC in preventing endometrioma recurrence. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Postoperative levonorgestrel-releasing intrauterine system versus oral contraceptives after gonadotropin-releasing hormone agonist treatment for preventing endometrioma recurrence | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Sihyun Cho | - |
dc.contributor.googleauthor | Ji Ann Jung | - |
dc.contributor.googleauthor | Yousun Lee | - |
dc.contributor.googleauthor | Hye Yeon Kim | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.contributor.googleauthor | Ji Sung Lee | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.identifier.doi | 10.1111/aogs.12294 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01174 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A03733 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J00022 | - |
dc.identifier.eissn | 1600-0412 | - |
dc.identifier.pmid | 24843434 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/aogs.12294/abstract | - |
dc.subject.keyword | Edema | - |
dc.subject.keyword | Pioglitazone | - |
dc.contributor.alternativeName | Kim, Hye Yeon | - |
dc.contributor.alternativeName | Seo, Seok Kyo | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.alternativeName | Jung, Ji Ann | - |
dc.contributor.alternativeName | Cho, Si Hyun | - |
dc.contributor.alternativeName | Choi, Young Sik | - |
dc.contributor.affiliatedAuthor | Kim, Hye Yeon | - |
dc.contributor.affiliatedAuthor | Seo, Seok Kyo | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Jung, Ji Ann | - |
dc.contributor.affiliatedAuthor | Cho, Si Hyun | - |
dc.contributor.affiliatedAuthor | Choi, Young Sik | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 93 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 38 | - |
dc.citation.endPage | 44 | - |
dc.identifier.bibliographicCitation | ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol.93(1) : 38-44, 2014 | - |
dc.identifier.rimsid | 54887 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.