Cited 3 times in
Feasibility and Outcomes of Hypofractionated Simultaneous Integrated Boost-Intensity Modulated Radiotherapy for Malignant Gliomas: A Preliminary Report
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김준원 | - |
dc.contributor.author | 박광우 | - |
dc.contributor.author | 서양권 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 이규성 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 차지혜 | - |
dc.contributor.author | 장지석 | - |
dc.date.accessioned | 2015-01-06T16:21:38Z | - |
dc.date.available | 2015-01-06T16:21:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97962 | - |
dc.description.abstract | PURPOSE: The aim of this study was to assess the feasibility and efficacy of hypofractionated simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) using three-layered planning target volumes (PTV) for malignant gliomas. MATERIALS AND METHODS: We conducted a retrospective analysis of 12 patients (WHO grade IV-10; III-2) postoperatively treated with SIB-IMRT with concurrent temozolomide. Three-layered PTVs were contoured based on gadolinium-enhanced magnetic resonance imaging as follows; high risk PTV (H-PTV) as the area of surgical bed including residual gross tumor with a 0.5 cm margin; low risk PTV (L-PTV) as the area surrounding the high risk PTV with 1.5 cm margin; moderate risk PTV (M-PTV) as a line at one-third the distance from high risk PTV to low risk PTV. Total dose to high risk PTV was 70 Gy in 8 and 62.5 Gy in 4 patients. RESULTS: The median follow-up time was 52 months in surviving patients. The 2- and 5-year overall survival (OS) rates were 66.6% and 47.6%, respectively. The 2- and 5-year progression-free survival (PFS) rates were 57.1% and 45.7%, respectively. The median OS and PFS were 48 and 31 months, respectively. Six patients (50%) progressed: in-field only in one, out-field or disseminated in 4, and both in one patient. All patients completed planned treatments without a toxicity-related gap. Asymptomatic radiation necrosis was observed in 4 patients at post-radiotherapy 9-31 months. CONCLUSION: An escalated dose of hypofractionated SIB-IMRT using three-layered PTVs can be safely performed in patients with malignant glioma, and might contribute to better tumor control and survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 70~77 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glioma/radiotherapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Radiotherapy, Intensity-Modulated/methods* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Young Adult | - |
dc.title | Feasibility and Outcomes of Hypofractionated Simultaneous Integrated Boost-Intensity Modulated Radiotherapy for Malignant Gliomas: A Preliminary Report | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Jihye Cha | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.contributor.googleauthor | Kwangwoo Park | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Kyu Sung Lee | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Joo Ho Kim | - |
dc.contributor.googleauthor | Yang-Gun Suh | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.identifier.doi | 10.3349/ymj.2014.55.1.70 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A01432 | - |
dc.contributor.localId | A01891 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A04009 | - |
dc.contributor.localId | A02682 | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 24339289 | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | hypofractionation | - |
dc.subject.keyword | intensity-modulated | - |
dc.subject.keyword | malignant glioma | - |
dc.subject.keyword | simultaneous integrated boost | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.alternativeName | Park, Kwang Woo | - |
dc.contributor.alternativeName | Suh, Yang Gun | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Lee, Kyu Sung | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Cha, Ji Hye | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | Park, Kwang Woo | - |
dc.contributor.affiliatedAuthor | Suh, Yang Gun | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Cha, Ji Hye | - |
dc.contributor.affiliatedAuthor | Lee, Kyu Sung | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 77 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.55(1) : 70-77, 2014 | - |
dc.identifier.rimsid | 53453 | - |
dc.type.rims | ART | - |
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