Cited 12 times in
MSX1 Polymorphism Associated with Risk of Oral Cleft in Korea: Evidence from Case-Parent Trio and Case-Control Studies
DC Field | Value | Language |
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dc.contributor.author | 강대용 | - |
dc.contributor.author | 고은나 | - |
dc.contributor.author | 김현석 | - |
dc.contributor.author | 남정모 | - |
dc.contributor.author | 박병윤 | - |
dc.contributor.author | 서일 | - |
dc.contributor.author | 윤지은 | - |
dc.contributor.author | 이종은 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2014-12-21T17:22:37Z | - |
dc.date.available | 2014-12-21T17:22:37Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/97472 | - |
dc.description.abstract | Orofacial clefts, including cleft lip with or without palate (CL/P) and cleft palate (CP), are one of the most common congenital malformations in Asian populations, where the rate of incidence is higher than in European or other racial groups. A number of candidate genes have been identified for orofacial clefts, although no single candidate has been consistently identified in all studies. We performed case-parent trio and case-control studies on 6 single nucleotide polymorphisms (SNPs) in the MSX1 gene using a sample of 52 CL/P and CP probands from Korea. In the case-control study, the allele frequencies of 6 MSX1 SNPs were compared between 52 oral cleft cases and 96 unmatched controls. For the case-parent trio study, single-marker and haplotype-based tests of transmission disequilibrium using allelic and genotypic tests revealed significant evidence of linkage in the presence of disequilibrium for 1170 G/A of exon 2. With the GG genotype as a reference group among GG, GA, and AA genotypes at 1170G/A, the disease risk decreased with the presence of the A allele (AA genotype: OR = 0.26, 95% CI = 0.10-0.99). These results are consistent with evidence from other studies in the US and Chile and confirm the importance of the MSX1 genotype in determining the risk of CL/P and CP in Koreans. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 101~108 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | MSX1 Polymorphism Associated with Risk of Oral Cleft in Korea: Evidence from Case-Parent Trio and Case-Control Studies | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Jungyong Park | - |
dc.contributor.googleauthor | Beyoung Yun Park | - |
dc.contributor.googleauthor | Terri H. Beaty | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Eun Na Go | - |
dc.contributor.googleauthor | Ji Eun Yun | - |
dc.contributor.googleauthor | Suk Kim | - |
dc.contributor.googleauthor | Dae Ryong Kang | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.contributor.googleauthor | Il Suh | - |
dc.contributor.googleauthor | Jong Eun Lee | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.identifier.doi | 10.3349/ymj.2007.48.1.101 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00137 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A01476 | - |
dc.contributor.localId | A01899 | - |
dc.contributor.localId | A02608 | - |
dc.contributor.localId | A03965 | - |
dc.contributor.localId | A03146 | - |
dc.contributor.localId | A01112 | - |
dc.contributor.localId | A00009 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.contributor.alternativeName | Kang, Dae Ryong | - |
dc.contributor.alternativeName | Go, Eun Na | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Park, Beyoung Yun | - |
dc.contributor.alternativeName | Suh, Il | - |
dc.contributor.alternativeName | Yun, Ji Eun | - |
dc.contributor.alternativeName | Lee, Jong Eun | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Go, Eun Na | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Park, Beyoung Yun | - |
dc.contributor.affiliatedAuthor | Suh, Il | - |
dc.contributor.affiliatedAuthor | Yun, Ji Eun | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Lee, Jong Eun | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | Kang, Dae Ryong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 48 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 108 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.48(1) : 101-108, 2007 | - |
dc.identifier.rimsid | 55899 | - |
dc.type.rims | ART | - |
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