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An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients

Authors
 Yeon Ho Choi  ;  Sun Young Rha  ;  Hyun Cheol Chung  ;  Jae Kyung Roh  ;  Byung Soo Kim  ;  Jin Ho Yoo  ;  Woo Ick Yang  ;  Hei Cheul Jeung 
Citation
 ONCOLOGIST, Vol.12(6) : 622-630, 2007 
Journal Title
ONCOLOGIST
ISSN
 1083-7159 
Issue Date
2007
Abstract
PURPOSE:
We examined the pattern of single-nucleotide polymorphisms (SNPs) of gemcitabine metabolism-related and target genes in breast cancer patients and evaluated their association with drug response or toxicity.
PATIENTS AND METHODS:
SNPs in deoxycytidine kinase (dCK), deoxycytidine monophosphate deaminase (DCTD), and ribonucleotide reductase M1 polypeptide (RRM1) were analyzed with genomic DNA of 10 breast cancer cell lines, 74 peripheral blood mononuclear cell (PBMC) samples from advanced breast cancer patients treated with gemcitabine, and 56 PBMC samples from healthy volunteers.
RESULTS:
The incidences of SNPs of breast cancer patients were 1.4% in dCK (626 A>G), 10.8% in DCTD (315 T>C), 40.5% in the first RRM1 (1082 C>A), 44.6% in the second RRM1 (2455 A>G), 44.6% in the third RRM1 (2464 G>A), and 23% in two RRM1 sites (2455 A>G and 2464 G>A) that were similar to those of the normal control group. We found a double SNP of RRM1 (2455 A>G and 2464 G>A) to be the novel haplotype that was associated with a lower frequency of chemotherapy-induced toxicity, such as neutropenia (p < .01) and G-CSF requirement (p < .005).
CONCLUSION:
RRM1 haplotype showed an association with susceptibility to gemcitabine monotherapy in breast cancer patients.
Files in This Item:
T200700870.pdf Download
DOI
10.1634/theoncologist.12-6-622
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Roh, Jae Kyung(노재경)
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
Choi, Yeon Ho(최연호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/97216
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