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Anti-PF4/Heparin 항체 양성의 헤파린 유도 혈소판감소증 1예
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송경순 | - |
dc.contributor.author | 송재우 | - |
dc.date.accessioned | 2014-12-21T17:05:45Z | - |
dc.date.available | 2014-12-21T17:05:45Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1738-7949 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96937 | - |
dc.description.abstract | Heparin-induced thrombocytopenia (HIT) is usually caused by anti-platelet factor 4 (PF4)/heparin antibodies, leading to intravascular platelet activation. Circulating anti-PF4/heaprin antibody (IgG, IgA and IgM) was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France) in a 61-year-old man with coronary artery disease and dyspnea on exercise. He had undergone a coronoary angiography using 2,000 unit of heparin before a procedure. On admission, laboratory testing revealed a platelet count of 296×109/L and aPTT (activated partial thromboplastin time) of 38.1 sec. The fall in the platelet count was progressive, resulting in 42% and 53% of platelet counts on the 6th and 12th days after intravenous heparin administration, respectively. He was discharged after coronary artery bypass graft. On discharge, platelet count was normalized to be 212×109/L. On the 7th day after dischage, anti-PF4/heaprin antibody was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 67~70 | - |
dc.relation.isPartOf | Korean Journal of Hematology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Anti-PF4/Heparin 항체 양성의 헤파린 유도 혈소판감소증 1예 | - |
dc.title.alternative | A Case of Heparin Induced Thrombocytopenia with Circulating Anti-PF4/Heparin Antibody | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | 송경순 | - |
dc.contributor.googleauthor | 이양순 | - |
dc.contributor.googleauthor | 송재우 | - |
dc.contributor.googleauthor | 김주원 | - |
dc.identifier.doi | 10.5045/kjh.2007.42.1.67 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02011 | - |
dc.contributor.localId | A02054 | - |
dc.relation.journalcode | J02033 | - |
dc.contributor.alternativeName | Song, Kyung Soon | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | Song, Kyung Soon | - |
dc.contributor.affiliatedAuthor | Song, Jae Woo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 67 | - |
dc.citation.endPage | 70 | - |
dc.identifier.bibliographicCitation | Korean Journal of Hematology, Vol.42(1) : 67-70, 2007 | - |
dc.identifier.rimsid | 37664 | - |
dc.type.rims | ART | - |
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