Antibody conjugated magnetic PLGA nanoparticles for diagnosis and treatment of breast cancer

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Authors: Choong-Hwan Lee ; Jaemoon Yang ; Seungjoo Haam ; Yong-Min Huh ; Ho-Geun Yoon ; Jin-Suck Suh ; Yong Jin Song ; Eun-Kyung Lim ; Sungbaek Seo ; Joseph Park

Abstract: DOX–magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric nanoparticles did not inhibit the nanoparticle formulation or drug release kinetics. The multimodal nanoparticles demonstrated remarkable cancer cell affinity and ultrasensitivity via magnetic resonance imaging. Furthermore, the loaded anticancer drugs were released and sustained for three weeks.

Full Text: http://pubs.rsc.org/en/Content/ArticleLanding/2007/JM/b702538f#!divAbstract

Appears in Collections:: 1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

Yonsei Authors: Suh, Jin Suck(서진석) https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) https://orcid.org/0000-0001-7365-0395
Yoon, Ho Geun(윤호근) https://orcid.org/0000-0003-2718-3372
Huh, Yong Min(허용민) https://orcid.org/0000-0002-9831-4475

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