Cited 40 times in
Expression and role of estrogen receptor α and β in medullary thyroid carcinoma: Different roles in cancer growth and apoptosis
DC Field | Value | Language |
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dc.contributor.author | 남기현 | - |
dc.contributor.author | 노태웅 | - |
dc.contributor.author | 박정수 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 이유미 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 임승길 | - |
dc.contributor.author | 정웅윤 | - |
dc.contributor.author | 조미애 | - |
dc.date.accessioned | 2014-12-21T16:46:07Z | - |
dc.date.available | 2014-12-21T16:46:07Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0892-7790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/96318 | - |
dc.description.abstract | Medullary thyroid carcinoma (MTC) originates from parafollicular C cells. Estrogen receptor beta(ERbeta) expressionwas detected in normal parafollicular C cells and MTC tumor tissue, but ERalpha expression in MTC tumors still remains undetermined. The appearance and loss of ERalpha or ERbeta expression has been known to play a role in the development and progression of many human cancers. We performed immunohistochemical studies of ERalpha, ERbeta, and Ki67, a mitotic index, in 11 human MTC tissue samples. ERalpha was detected in 10 cases (91%), and ERbeta expression was observed in 8 cases (72.7%). A majority (8/10) of ERalpha-positive tumors showing ERbeta Ki67 expression was detected in three cases (27.3%). Neither clinical parameters nor tumor node metastasis (TNM) tumor staging was correlated with the positivity for ERs or Ki67. To investigate the biological role of each ER, we used ER-negative MTC TT cells and adenoviral vectors carrying ERalpha (Ad-ERalpha), ERbeta (Ad-ERbeta), estrogen response element (ERE)-Luc (Ad-ERE-Luc), and activator protein 1 (AP1)-Luc (Ad-AP1-Luc). Estrogen stimulated and anti-estrogen, ICI 182 780, suppressed ERE reporter activity in TT cells expressing ERalpha or ERbeta, suggesting that both ERs use the same classical ERE-mediated pathway. Ad-ERalpha infection stimulated TT cell growth; in contrast, Ad-ERbeta infection suppressed their growth. Apoptosis was detected in Ad-ERbeta-infected TT cells. Estrogen and anti-estrogen suppressed AP1 activity in Ad-ERalpha-infected cells, whereas upon Ad-ERbeta infection estrogen further stimulated AP1 activity which in turn is suppressed by anti-estrogen, suggesting that each ER acts differently through a non-ERE-mediated pathway. Our results suggest that ERalpha and ERbeta may play different roles in MTC tumor growth and progression. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | JOURNAL OF ENDOUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Expression and role of estrogen receptor α and β in medullary thyroid carcinoma: Different roles in cancer growth and apoptosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Mi Ae Cho | - |
dc.contributor.googleauthor | Mi Kyung Lee | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Sung-Kil Lim | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Taewoong Noh | - |
dc.contributor.googleauthor | Ju Hyeong Lee | - |
dc.contributor.googleauthor | Cheong Soo Park | - |
dc.contributor.googleauthor | Woung Youn Chung | - |
dc.contributor.googleauthor | Kee-Hyun Nam | - |
dc.identifier.doi | 10.1677/JOE-06-0193 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01245 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03375 | - |
dc.contributor.localId | A03674 | - |
dc.contributor.localId | A03816 | - |
dc.contributor.localId | A02768 | - |
dc.contributor.localId | A01298 | - |
dc.contributor.localId | A01646 | - |
dc.relation.journalcode | J01394 | - |
dc.identifier.eissn | 1557-900X | - |
dc.contributor.alternativeName | Nam, Kee Hyun | - |
dc.contributor.alternativeName | Noh, Tae Woong | - |
dc.contributor.alternativeName | Park, Cheong Soo | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Lee, Mi Kyung | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Lim, Sung Kil | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.alternativeName | Cho, Mi Ae | - |
dc.contributor.affiliatedAuthor | Nam, Kee Hyun | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Lim, Sung Kil | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Cho, Mi Ae | - |
dc.contributor.affiliatedAuthor | Lee, Mi Kyung | - |
dc.contributor.affiliatedAuthor | Noh, Tae Woong | - |
dc.contributor.affiliatedAuthor | Park, Cheong Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 195 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 255 | - |
dc.citation.endPage | 263 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENDOUROLOGY, Vol.195(2) : 255-263, 2007 | - |
dc.identifier.rimsid | 37009 | - |
dc.type.rims | ART | - |
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