In this paper, we propose a simple and relative electrode contact monitoring method. By exploiting the power line interference, which is regarded as one of the worst noise sources for bio-potential measurement, the relative difference in electrode impedance can be measured without a current or voltage source. Substantial benefits, including no extra circuit components, no degradation of the body potential driving circuit, and no electrical safety problem, can be achieved using this method. Furthermore, this method can be applied to multi-channel isolated bio-potential measurement systems and home health care devices under a steady measuring environment.