Cited 33 times in
Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 박찬미 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 하종원 | - |
dc.date.accessioned | 2014-12-21T16:33:49Z | - |
dc.date.available | 2014-12-21T16:33:49Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0954-6928 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95922 | - |
dc.description.abstract | BACKGROUND: Pregnancy-associated plasma protein-A (PAPP-A) is a high-molecular-weight, zinc-binding matrix metalloproteinase that is known to be abundantly expressed in ruptured plaques. Previous studies have shown PAPP-A to be a significant marker of plaque instability and cardiovascular events in patients with acute coronary syndromes. Because the activity of PAPP-A may be modulated by genetic variants in the PAPP-A genes, we tried to determine the association of PAPP-A gene with acute myocardial infarction (AMI). METHODS: We analyzed four single nucleotide polymorphisms (SNPs) of PAPP-A gene variants and seven other polymorphisms of cytokine genes that have been reported to have functional significance (RANTES G-403A, MCP1 G-2518A, CRP A2147G, CRP G-717A, AGER G557A, LTA T26A, IL-6 G-572C) for possible association with AMI in 170 unrelated AMI patients and unrelated age-matched controls, respectively. RESULTS: The average age of the study population was 62.2+/-11.4 years in AMI patients and 62.6+/-10.4 years in healthy controls. Multiple logistic regression analysis with risk factors such as age, male sex, smoking, hypertension, diabetes mellitus, and dyslipidemia revealed the PAPP-A IVS6+95 C allele to be associated with an increased risk of AMI (dominancy: odds ratio, 2.13; 95% confidence interval, 1.12-4.07; P=0.022; codominancy: odds ratio, 1.89; 95% confidence interval, 1.14-3.16; P=0.015). CONCLUSIONS: We found, for the first time, that PAPP-A IVS6+95 C allele is an independent risk factor for AMI even after adjustment for traditional risk factors. The determination of such genotype contributing to AMI could provide a new tool for identifying high-risk individuals. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 417~422 | - |
dc.relation.isPartOf | CORONARY ARTERY DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biostatistics (의학통계학) | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Jong-Chan Youn | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jong-Won Ha | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Chan-Mi Park | - |
dc.contributor.googleauthor | Dong-Jik Shin | - |
dc.identifier.doi | 10.1097/MCA.0b013e328241d967 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A01708 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04257 | - |
dc.relation.journalcode | J00649 | - |
dc.identifier.eissn | 1473-5830 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00019501-200709000-00001&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Park, Chan Mi | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Ha, Jong Won | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Park, Chan Mi | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Ha, Jong Won | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 417 | - |
dc.citation.endPage | 422 | - |
dc.identifier.bibliographicCitation | CORONARY ARTERY DISEASE, Vol.18(6) : 417-422, 2007 | - |
dc.identifier.rimsid | 53291 | - |
dc.type.rims | ART | - |
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