Cited 6 times in
Association of RAGE Gene Polymorphisms with In-Stent Restenosis in Non-Diabetic Korean Population
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 심지영 | - |
dc.contributor.author | 윤세정 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2014-12-21T16:29:45Z | - |
dc.date.available | 2014-12-21T16:29:45Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0008-6312 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/95800 | - |
dc.description.abstract | BACKGROUND: Interaction between advanced glycosylation end products (AGEs) and receptor for AGEs (RAGE) in vessel wall may lead to inflammation, smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal hyperplasia and restenosis. We investigated the possibility that single nucleotide polymorphisms of the genes encoding RAGE are associated with in-stent restenosis after coronary stenting. METHODS: Our study included 334 consecutive non-diabetic male patients with symptomatic coronary artery disease who underwent bare metal stent implantation. Follow-up angiography was performed in 297 patients (88.9%), 6 months after intervention. We screened -1106T-->C, -443T-->C, -388T-->A, -257G-->A, +557G-->A and +1704G-->T RAGE polymorphisms in these patients. Genotyping was performed by single base extension with amplifying primers and probes for TaqMan. RESULTS: A total of 355 target lesions were evaluated, in 297 patients. There was no significant association of the -1106T-->C, -443T-->C, -388T-->A, -257G-->A, +557G-->A or +1704G-->T polymorphisms with in-stent restenosis after coronary artery stenting. We did not observe a significant difference between the genotype distributions and the rates of angiographic restenosis between the polymorphisms. In a multivariate analysis of angiographic restenosis, we examined the possible influence of the baseline, lesion-related, and procedural variables. After adjustment for these potentially confounding factors, the multivariate analysis did not reveal an association of polymorphism with angiographic restenosis. CONCLUSION: Our observation suggests that the RAGE gene polymorphism is not associated with in-stent restenosis after coronary artery stenting in non-diabetic patients in the Korean population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 261~268 | - |
dc.relation.isPartOf | CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Association of RAGE Gene Polymorphisms with In-Stent Restenosis in Non-Diabetic Korean Population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Chi Young Shim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Chanmi Park | - |
dc.contributor.googleauthor | Bermseok Oh | - |
dc.contributor.googleauthor | Hung Tae Kim | - |
dc.contributor.googleauthor | Hyun-Young Park | - |
dc.contributor.googleauthor | Se-Jung Yoon | - |
dc.identifier.doi | 10.1159/000095516 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02213 | - |
dc.contributor.localId | A02569 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03585 | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J00457 | - |
dc.identifier.eissn | 1421-9751 | - |
dc.identifier.url | http://www.karger.com/Article/FullText/95516 | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Shim, Chi Young | - |
dc.contributor.alternativeName | Yoon, Se Jung | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Shim, Chi Young | - |
dc.contributor.affiliatedAuthor | Yoon, Se Jung | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 107 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 261 | - |
dc.citation.endPage | 268 | - |
dc.identifier.bibliographicCitation | CARDIOLOGY, Vol.107(4) : 261-268, 2007 | - |
dc.identifier.rimsid | 51549 | - |
dc.type.rims | ART | - |
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