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Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis

Title
 Local anesthetics inhibit tissue factor expression in activated monocytes via inhibition of tissue factor mRNA synthesis 
Authors
 Ji-Eun Kim ; Ki Jun Kim ; Hyun Kyung Kim ; Kyou-Sup Han ; Wonsik Ahn 
Issue Date
2011
Journal Title
 Clinical and Applied Thrombosis-Hemostasis 
ISSN
 1076-0296 
Citation
 Clinical and Applied Thrombosis-Hemostasis, Vol.17(6) : E4~E9, 2011 
Abstract
Local anesthetics have been reported to have anticoagulant properties, but the mechanisms responsible for this action are poorly understood. Here, we evaluated the in vitro effects of 3 local anesthetics--lidocaine, ropivacaine, and bupivacaine--on the tissue factor expression by monocytes. Monocytes from peripheral blood were stimulated with lipopolysaccharide (LPS) in the presence or absence of local anesthetics. All 3 local anesthetics inhibited the expression of tissue factor antigen and tissue factor activity in LPS-stimulated monocytes in a dose- and time-dependent manner and reduced tissue factor messenger RNA (mRNA) expression in endothelial cells and a monocytic cell line. None of the 3 drugs induced apoptosis or affected the viability of monocytes. Our findings that local anesthetics inhibited the tissue factor induction in activated monocytes by inhibiting tissue factor mRNA level may demonstrate the feasibility of using local anesthetics in hypercoagulable and inflammatory conditions
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/95304
DOI
10.1177/1076029610378500
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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Link
 http://cat.sagepub.com/content/17/6/E4
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