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Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea

Title
 Fecal colonization of Enterobacteriaceae carrying plasmid-mediated quinolone resistance determinants in Korea 
Authors
 Haeng Soon Jeong ; Il Kwon Bae ; Jeong Nyeo Lee ; Nam Hee Ryoo ; Chae Hoon Lee ; Sunjoo Kim ; Joseph Jeong ; Chulhun L. Chang ; Si Hyun Kim ; Jeong Hwan Shin 
Issue Date
2011
Journal Title
 Microbial Drug Resistance 
ISSN
 1076-6294 
Citation
 Microbial Drug Resistance, Vol.17(4) : 507~512, 2011 
Abstract
The aims of the current study were to investigate the prevalence and molecular characteristics of plasmid-mediated quinolone resistance (PMQR) genes from colonizing fecal organisms and to compare the incidence and subtype of these genes according to bacterial species and hospital at five tertiary-care hospitals in Korea. A total of 500 nonduplicated clinical isolates of Enterobacteriaceae were obtained from fecal specimens at five tertiary-care hospitals between March and May 2008. The PMQR genes (qnrA, qnrB, qnrS, aac(6')-Ib-cr, and qepA) were amplified by PCR and confirmed by direct sequencing of the PCR products. A total of 83 (16.6%) qnr-positive isolates were detected. The prevalence rates of qnrA, qnrB, and qnrS were 1.4%, 13.6%, and 1.6%, respectively. The species distributions of qnrB-positive isolates were Klebsiella pneumoniae (37/109; 33.9%), Citrobacter freundii (10/34; 29.4%), Citrobacter braakii (8/13; 61.5%), and Escherichia coli (8/275; 2.9%). Sixteen subtypes of qnrB were detected, including seven novel variants. The prevalences of aac(6')-Ib-cr and qepA were 15.6% (n=78) and 0.6% (n=3), respectively. The aac(6')-Ib-cr gene was detected in 39 (47.0%) of 83 qnr-positive isolates and 39 (9.4%) of 417 qnr-negative isolates There was one qepA variant containing a novel mutation (Ala231Val). The prevalence of PMQR genes was high in Enterobacteriaceae from stool specimens in Korea, and there was a close relation between qnr and aac(6')-Ib-cr.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/95249
DOI
10.1089/mdr.2011.0040
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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Link
 http://online.liebertpub.com/doi/abs/10.1089/mdr.2011.0040
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