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Serum cystatin C reflects the progress of albuminuria

Title
Serum cystatin C reflects the progress of albuminuria
Authors
Jeong Seon Yoo;Young Mi Lee;Kyung Rae Kim;Young Duk Song;Chul Woo Ahn;Joo Young Nam;Jong Suk Park;Shin Ae Kang;Ki-Cheon Jeong;Shin Young Lee;Ji Woon Kim;Eun Hae Lee
Issue Date
2011
Journal Title
Diabetes & Metabolism Journal
ISSN
2233-6079
Citation
Diabetes & Metabolism Journal, Vol.35(6) : 602~609, 2011
Abstract
BACKGROUND: Research on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate. METHODS: We enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic. RESULTS: With the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR. CONCLUSION: Serum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/95154
DOI
10.4093/dmj.2011.35.6.602
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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