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Immunizing children aged 9 to 15 months with live attenuated SA14-14-2 Japanese encephalitis vaccine in Thailand.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손영모 | - |
dc.contributor.author | 오희철 | - |
dc.date.accessioned | 2014-12-20T17:35:40Z | - |
dc.date.available | 2014-12-20T17:35:40Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0125-2208 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94896 | - |
dc.description.abstract | The authors aimed to evaluate the safety and immunogenicity of a live attenuated SA14-14-2 Japanese Encephalitis (JE) vaccine in healthy Thai infants. One hundred and fifty subjects aged 9-15 months were vaccinated with one dose of this vaccine. Regarding the vaccine safety, during the 28-day post-vaccination follow-up, no vaccine-related serious adverse events were reported. In terms of immunogenicity, the sero-conversion rate of a single dose vaccination was 95% (95% CI, 90.0-97.6%) within 90 days after vaccination and the geometric mean titer (GMT) was 66.1. Eight subjects with JE seronegative on days 28-35 post-vaccination became sero-positive on day 90. Seven subjects who remained sero-negative during days 28-35 and day 90 post-vaccination were successfully sero-converted after receiving a second dose 3 months later. Thus, two doses of this JE vaccine resulted in a 100% (95% CI, 97.3-100%) sero-conversion rate with the GMT of 260.8. Eight children with GMTs lower than protective level after a single vaccination demonstrated a booster response with GMT of 1237 after the second dose of JE vaccination. In conclusion, the live attenuated SA14-14-2 vaccine was safe, well tolerated and highly immunogenic with 95% and 100% sero-conversion rate after one and two doses, respectively. Nevertheless, its long-term immune response and possible influences from natural dengue infection requires further evaluati | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | s195~s203 | - |
dc.relation.isPartOf | JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antibodies, Viral/blood | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Encephalitis Virus, Japanese/immunology* | - |
dc.subject.MESH | Encephalitis, Japanese/prevention & control* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Hemolytic Plaque Technique | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunization | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Japanese Encephalitis Vaccines/administration & dosage | - |
dc.subject.MESH | Japanese Encephalitis Vaccines/immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neutralization Tests | - |
dc.subject.MESH | Thailand | - |
dc.subject.MESH | Vaccination | - |
dc.subject.MESH | Vaccines, Attenuated/administration & dosage* | - |
dc.subject.MESH | Vaccines, Attenuated/immunology | - |
dc.title | Immunizing children aged 9 to 15 months with live attenuated SA14-14-2 Japanese encephalitis vaccine in Thailand. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학) | - |
dc.contributor.googleauthor | Tawee Chotpitayasunondh | - |
dc.contributor.googleauthor | Young Mo Sohn | - |
dc.contributor.googleauthor | Sutee Yoksan | - |
dc.contributor.googleauthor | J. Min MSc | - |
dc.contributor.googleauthor | Heechoul Ohrr | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01981 | - |
dc.contributor.localId | A02419 | - |
dc.relation.journalcode | J01895 | - |
dc.identifier.pmid | 22043776 | - |
dc.subject.keyword | geometric mean titer | - |
dc.subject.keyword | seroprotection | - |
dc.subject.keyword | live attenuated chimeric JE vaccine | - |
dc.subject.keyword | JE-CV | - |
dc.subject.keyword | SA14-14-2 vaccine | - |
dc.contributor.alternativeName | Sohn, Young Mo | - |
dc.contributor.alternativeName | Ohrr, Hee Choul | - |
dc.contributor.affiliatedAuthor | Sohn, Young Mo | - |
dc.contributor.affiliatedAuthor | Ohrr, Hee Choul | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 94 | - |
dc.citation.number | Suppl 3 | - |
dc.citation.startPage | 195 | - |
dc.citation.endPage | 203 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND, Vol.94(Suppl 3) : 195-203, 2011 | - |
dc.identifier.rimsid | 27834 | - |
dc.type.rims | ART | - |
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