Retrospective Multicenter Study on Clinical Aspects in Premature Ovarian Failure
Journal of Korean Society of Menopause(대한폐경학회지)
Journal of Korean Society of Menopause(대한폐경학회지), Vol.17(3) : 160~165, 2011
Objectives: Premature ovarian failure (POF) is a syndrome defined as the cessation of ovarian function before the age of 40 years
that is characterized by amenorrhoea associated with elevated gonadotropin levels. The aim of this study was to compare clinical
manifestation of primary amenorrhea and secondary amenorrhea group.
Methods: This study was designed as a retrospective multicenter study of 262 women with premature ovarian failure. Sixty eight
women with primary amenorrhea and 194 women with secondary amenorrhea were evaluated and hormonal level, lipid profile, bone
mineral density, and pregnancy rates were compared.
Results: The estradiol level was markedly lower in primary amenorrhea than secondary amenorrhea. The pregnancy rate of 43.3%
before the diagnosis in secondary amenorrhea was markedly higher than the rate of 0% in primary amenorrhea. The pregnancy rates
after treatment was 5.9% in primary amenorrhea, but 1.0% after diagnosis and 2.8% after treatment in secondary amenorrhea. The
pregnancy rate after hormonal treatment was 3.7% in total, 8.3% in primary amenorrhea, and 2.8% in secondary amenorrhea. In nine
cases of pregnancy, seven cases were after estrogen-progestin (EP), one case was after clomiphene citrate and one case was after
EP/human menopausal gonodotropin (hMG). And In nine cases of pregnancy, six cases resulted from oocyte donation. The
prevalence of osteopenia/osteoporosis was markedly higher in primary amenorrhea than in secondary amenorrhea.
Conclusion: Premature ovarian failure has negative influences on the physical and psychological health of young patients. Effective
management should include earlier diagnosis and intensive medical intervention to relieve symptoms of estrogen deficiency and to
treat long-term disease such as osteoporosis and in assisted pregnancy by oocyte donation.