The increasing prevalence of antimicrobial-resistant bacteria has become a serious
problem in many parts of the world, including Korea. The resistance of of Grampositive
cocci was once considered to be a more serious problem, but the recent
emergence of multi-resistant Gram-negative bacilli has raised great concerns.
In Korea, the prevalence of ESBL-producing Escherichia coli and Klebsiella
pneumoniae and fluoroquinolone-resistant E. coli , K. pneumoniae, Acinetobacter
spp., and Pseudomonas aeruginosa has gradually increased. The increase in
imipenem resistance was slight in P. aeruginosa , but drastic in Acinetobacter spp.
It is certain that problematic antimicrobial-organism combinations are prevalent in
Korea, increase of resistant bacteria will continue in the future. The development
of new antimicrobial agents is considered difficult. Therefore, it is very important
to use existing antimicrobial agents prudently, to extend the efficacy, to prevent
infections, and tostrengthen infection control measures to prevent spread of