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A novel pro-lymphangiogenic function for Th17/IL-17

Authors
 Sunil K. Chauhan ; Yiping Jin ; Reza Dana ; Hyung Keun Lee ; Thomas A. Fuchsluger ; Hyun Soo Lee ; Sunali Goyal 
Citation
 Blood, Vol.118(17) : 4630~4634, 2011 
Journal Title
 Blood 
ISSN
 0006-4971 
Issue Date
2011
Abstract
Th17 cells, in addition to their proinflammatory functions, have been recognized as potent inducers of angiogenesis in autoimmune diseases and malignancies. In the present study, we demonstrate distinct mechanisms by which IL-17 induces lymphangiogenesis. Using the mouse cornea micropocket and cell culture assays, our data demonstrate that IL-17 directly promotes growth of lymphatic vessels by inducing increased expression of prolymphangiogenic VEGF-D and proliferation of lymphatic endothelial cells. However, IL-17-induced growth of blood vessels is primarily mediated through IL-1β secretion by IL-17-responsive cells. Furthermore, in vivo blockade of IL-17 in a preclinical model of Th17-dominant autoimmune ocular disease demonstrates a significant reduction in the corneal lymphangiogenesis and in the progression of clinical disease. Taken together, our findings demonstrate a novel prolymphangiogenic function for Th17/IL-17, indicating that IL-17 can promote the progression and amplification of immunity in part through its induction of lymphangiogenesis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94853
DOI
10.1182/blood-2011-01-332049
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Ophthalmology
Yonsei Authors
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