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Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2014-12-20T17:34:05Z | - |
dc.date.available | 2014-12-20T17:34:05Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/94844 | - |
dc.description.abstract | BACKGROUND: The Asia-specific PLA2G7 994G-T transversion leads to V279F substitution within the lipoprotein-associated phospholipase-A2 (Lp-PLA₂) and to absence of enzyme activity in plasma. This variant offers a unique natural experiment to assess the role of Lp-PLA₂ in the pathogenesis of coronary artery disease (CAD) in humans. Given conflicting results from mostly small studies, a large two-stage case-control study was warranted. METHODOLOGY/PRINCIPAL FINDINGS: PLA2G7 V279F genotypes were initially compared in 2890 male cases diagnosed with CAD before age 60 with 3128 male controls without CAD at age 50 and above and subsequently in a second independent male dataset of 877 CAD cases and 1230 controls. In the first dataset, the prevalence of the 279F null allele was 11.5% in cases and 12.8% in controls. After adjustment for age, body mass index, diabetes, smoking, glucose and lipid levels, the OR (95% CI) for CAD for this allele was 0.80 (0.66-0.97, p = 0.02). The results were very similar in the second dataset, despite lower power, with an allele frequency of 11.2% in cases and 12.5% in controls, leading to a combined OR of 0.80 (0.69-0.92), p = 0.002. The magnitude and direction of this genetic effect were fully consistent with large epidemiological studies on plasma Lp-PLA₂ activity and CAD risk. CONCLUSIONS: Natural deficiency in Lp-PLA₂ activity due to carriage of PLA2G7 279F allele protects from CAD in Korean men. These results provide evidence for a causal relationship between Lp-PLA₂ and CAD, and support pharmacological inhibition of this enzyme as an innovative way to prevent CAD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e18208 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 1-Alkyl-2-acetylglycerophosphocholine Esterase/genetics* | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Coronary Artery Disease/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Dawn Waterworth | - |
dc.contributor.googleauthor | Jong-Eun Lee | - |
dc.contributor.googleauthor | Kijoung Song | - |
dc.contributor.googleauthor | Sujin Kim | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Kyung Woo Park | - |
dc.contributor.googleauthor | Hyun-Jai Cho | - |
dc.contributor.googleauthor | Il-Young Oh | - |
dc.contributor.googleauthor | Jeong Euy Park | - |
dc.contributor.googleauthor | Bok-Soo Lee | - |
dc.contributor.googleauthor | Hyo Jeong Ku | - |
dc.contributor.googleauthor | Dong-Jik Shin | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Bok-Ghee Han | - |
dc.contributor.googleauthor | Hye-Yoon Jang | - |
dc.contributor.googleauthor | Eun-Young Cho | - |
dc.contributor.googleauthor | Patrick Vallance | - |
dc.contributor.googleauthor | John Whittaker | - |
dc.contributor.googleauthor | Lon Cardon | - |
dc.contributor.googleauthor | Vincent Mooser | - |
dc.identifier.doi | 10.1371/journal.pone.0018208 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 21490708 | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 6 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | e18208 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.6(4) : e18208, 2011 | - |
dc.identifier.rimsid | 27792 | - |
dc.type.rims | ART | - |
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