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Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population.

Title
Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population.
Authors
Sang Yeun Kim;Sun Ju Lee;Hyoun Kyoung Park;Ji Eun Yun;Myoungsook Lee;Jidong Sung;Sun Ha Jee
Issue Date
2011
Journal Title
Epidemiology and health
ISSN
2092-7193
Citation
Epidemiology and health, Vol.33: e2011007, 2011
Abstract
OBJECTIVES: Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown. METHODS: The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis. RESULTS: WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women. CONCLUSION: These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94836
DOI
10.4178/epih/e2011007
Appears in Collections:
1. 연구논문 > 4. Graduate School of Public Health > Graduate School of Public Health
Yonsei Authors
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