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HBV genotypes: relevance to natural history, pathogenesis and treatment of chronic hepatitis B

Authors
 Beom Kyung Kim ; Peter A Revill ; Sang Hoon Ahn 
Citation
 Antiviral Therapy, Vol.16(8) : 1169~1186, 2011 
Journal Title
 Antiviral Therapy 
ISSN
 1359-6535 
Issue Date
2011
Abstract
Although chronic HBV infection is the leading cause of chronic liver disease and death worldwide, there are substantial differences in its clinical courses regarding prevalence, mode of transmission, characteristics of each phase, responses to antiviral therapy, and development of cirrhosis and hepatocellular carcinoma, according to geographical areas (Asia versus Western Europe and North America versus Africa). Furthermore, the clinical course in infected individuals depends on a complex interplay among various factors including viral, host, environmental and other factors. Recently, understanding of molecular characteristics of the prevailing HBV genotypes, frequently accompanied mutations and their clinical implications might explain these geographical differences more pertinently. Hence, in this article, we review the global epidemiology and the natural history of HBV infection, with emphasis on summarizing the different HBV genotypes according to regions.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94814
DOI
10.3851/IMP1982
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.intmedpress.com/journals/avt/article.cfm?id=1982&pid=88&sType=AVT
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