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Aging impairs vasodilatory responses in rats

Title
Aging impairs vasodilatory responses in rats
Authors
Soon Yul Kim;Jong Taek Park;Jae Chan Choi;Jeong Soo Lee;Jae Kyun Park
Issue Date
2011
Journal Title
Korean Journal of Anesthesiology
ISSN
2005-6419
Citation
Korean Journal of Anesthesiology, Vol.61(6) : 506~510, 2011
Abstract
BACKGROUND: Aging causes profound changes of stiffness and compliance in the cardiovascular system, which contributes to decreased cardiovascular reserve. Mechanisms of the underlying endothelial vasodilator dysfunction in vasodilator signaling pathways may occur at multiple sites within any of these pathways. METHODS: Age-related changes in the vasculature were investigated in adult young (3-6 months, Y) and old (26-29 month, O) Wistar rats (n = 6). The aortas were carefully dissected from the rat and cut into rings 1.5-2.0 mm in length to measure in vitro isometric tension. Vasorelaxant responses of aortic rings to acetylcholine (ACh), sodium nitroprusside (SNP) and P1075 were examined using Dose Response software (AD Instruments, Mountain View, CA). RESULTS: Endothelium-dependent vasodilator function was impaired. The endothelium of aging rats impaired endothelial NO dependent vasodilation, but the machinery for vasodilation was not impaired. CONCLUSIONS: Age-related NO-mediated vasorelaxation in the aging endothelium was inhibited and appears to be major mechanism of vascular change and impaired vascular regulation.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94766
DOI
10.4097/kjae.2011.61.6.506
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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