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Severe Symptomatic Hyponatremia Caused by Low Dose Oral Cyclophosphamide: A Case Report

Title
 Severe Symptomatic Hyponatremia Caused by Low Dose Oral Cyclophosphamide: A Case Report
Authors
 Seungkyo Park; Woojeung Kim; Hyeong-Cheon Park; Sung Kyu Ha; Ji Hyun Yoon; Hoon Young Choi
Issue Date
2011
Journal Title
 Korean Journal of Nephrology
ISSN
 1975-9460
Citation
 Korean Journal of Nephrology, Vol.30(6) : 647~650, 2011
Abstract
Cyclophosphamide (CY), an alkylating agent, is frequently used in the treatment of various autoimmune disorders and malignancies. Acute hyponatremia is a well-known side effect of moderate to high dose intravenous CY treatment, but is rare in patients treated with low dose intravenous CY. We report the case of a severe symptomatic hyponatremia in a 68-year-old woman with renal impairment who was treated with oral CY (100 mg/day) for anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN). This case demonstrates that even oral CY could be associated with life threatening acute hyponatremia and should be used with caution.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94720
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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