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Retinoic acid modulates chondrogenesis in the developing mouse cranial base

Authors
 Hyuk-Jae Kwon ; Jeong-Oh Shin ; Han-Sung Jung ; Sung-Won Cho ; Min-Jung Lee ; Kyoung-Won Cho ; Jong-Min Lee 
Citation
 Journal of Experimental Zoology Part B-Molecular and Developmental Evolution , Vol.316(8) : 574~583, 2011 
Journal Title
 Journal of Experimental Zoology Part B-Molecular and Developmental Evolution 
ISSN
 1552-5007 
Issue Date
2011
Abstract
The retinoic acid (RA) signaling pathway is known to play important roles during craniofacial development and skeletogenesis. However, the specific mechanism involving RA in cranial base development has not yet been clearly described. This study investigated how RA modulates endochondral bone development of the cranial base by monitoring the RA receptor RARγ, BMP4, and markers of proliferation, programmed cell death, chondrogenesis, and osteogenesis. We first examined the dynamic morphological and molecular changes in the sphenooccipital synchondrosis-forming region in the mouse embryo cranial bases at E12-E16. In vitro organ cultures employing beads soaked in RA and retinoid-signaling inhibitor citral were compared. In the RA study, the sphenooccipital synchondrosis showed reduced cartilage matrix and lower BMP4 expression while hypertrophic chondrocytes were replaced with proliferating chondrocytes. Retardation of chondrocyte hypertrophy was exhibited in citral-treated specimens, while BMP4 expression was slightly increased and programmed cell death was induced within the sphenooccipital synchondrosis. Our results demonstrate that RA modulates chondrocytes to proliferate, differentiate, or undergo programmed cell death during endochondral bone formation in the developing cranial base.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94588
DOI
10.1002/jez.b.21432
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/jez.b.21432/abstract
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