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Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia

Title
 Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia 
Authors
 Ga Hyun Son ; Jeong Hyeon Kim ; Ja Young Kwon ; Yong Won Park ; Young Han Kim ; Jung Hae Hwang 
Issue Date
2011
Journal Title
 Hypertension in Pregnancy 
ISSN
 1064-1955 
Citation
 Hypertension in Pregnancy, Vol.30(4) : 408~413, 2011 
Abstract
OBJECTIVE: The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia. METHODS: A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine. RESULTS: Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls. CONCLUSION: In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94559
DOI
10.3109/10641955.2010.507841
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
1. 연구논문 > 1. College of Medicine > Medical Research Center
Yonsei Authors
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Link
 http://informahealthcare.com/doi/abs/10.3109/10641955.2010.507841
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