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Urinary excretion of nephrin in patients with severe preeclampsia. Urinary nephrin in preeclampsia

Authors
 Ga Hyun Son ; Jeong Hyeon Kim ; Ja Young Kwon ; Yong Won Park ; Young Han Kim ; Jung Hae Hwang 
Citation
 Hypertension in Pregnancy, Vol.30(4) : 408~413, 2011 
Journal Title
 Hypertension in Pregnancy 
ISSN
 1064-1955 
Issue Date
2011
Abstract
OBJECTIVE: The objective of this study was to examine whether nephrin is present in the urine of patients with severe preeclampsia. METHODS: A total of 45 women were recruited for this study, and 25 of these patients had severe preeclampsia. Twenty gestational age-matched normotensive women without proteinuria served as a control group. Urine samples were collected close to delivery, typically ≤24 h before delivery. Western blot analysis was performed to assess the excretion of nephrin in urine. RESULTS: Nephrin was detected in all urine samples from all the women with severe preeclampsia but not in urine from normotensive controls. CONCLUSION: In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94559
DOI
10.3109/10641955.2010.507841
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
1. 연구논문 > 1. College of Medicine > Medical Research Center
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Link
 http://informahealthcare.com/doi/abs/10.3109/10641955.2010.507841
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