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Effects of leptin and adiponectin on pancreatic β-cell function

Authors
 Yong-ho Lee  ;  Faidon Magkos  ;  Christos S. Mantzoros  ;  Eun Seok Kang 
Citation
 METABOLISM-CLINICAL AND EXPERIMENTAL, Vol.60(12) : 1664-1672, 2011 
Journal Title
METABOLISM-CLINICAL AND EXPERIMENTAL
ISSN
 0026-0495 
Issue Date
2011
MeSH
Adiponectin/metabolism ; Adiponectin/physiology* ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Clinical Trials as Topic ; Epidemiologic Studies ; Gene Expression Regulation/drug effects ; Humans ; Insulin/metabolism* ; Insulin/secretion ; Insulin Resistance ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism* ; Leptin/metabolism ; Leptin/physiology*
Abstract
Leptin and adiponectin are hormones secreted from adipocytes that have important roles in metabolism and energy homeostasis. This review evaluates the effects of leptin and adiponectin on β-cell function by analyzing and compiling results from human clinical trials and epidemiologic studies as well as in vitro and in vivo experiments. Leptin has been shown to inhibit ectopic fat accumulation and thereby prevent β-cell dysfunction and protect the β-cell from cytokine- and fatty acid-induced apoptosis. However, leptin suppresses insulin gene expression and secretion as well as glucose transport into the β-cell. Adiponectin stimulates insulin secretion by enhancing exocytosis of insulin granules and upregulating the expression of the insulin gene; however, this effect depends on the prevailing glucose concentration and status of insulin resistance. In addition, adiponectin has antiapoptotic properties in β-cells. Available evidence concerning the role of these adipokines on insulin secretion, insulin gene expression, and apoptosis is not always entirely consistent; and many fundamental questions remain to be answered by future studies
Full Text
http://www.sciencedirect.com/science/article/pii/S0026049511001119
DOI
10.1016/j.metabol.2011.04.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94540
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