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Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells

Authors
 민유홍 ; 정회경 
Citation
 Molecules and Cells, Vol.32(3) : 243~249, 2011 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2011
Abstract
Resveratrol is a plant phenolic phytoalexin that has been reported to have antitumor properties in several types of cancers. In particular, several studies have suggested that resveratrol exerts antiproliferative effects against A549 human non-small cell lung cancer cells; however, its mechanism of action remains incompletely understood. Deregulation of microRNAs (miRNAs), a class of small, noncoding, regulatory RNA molecules involved in gene expression, is strongly correlated with lung cancer. In this study, we demonstrated that resveratrol treatment altered miRNA expression in A549 cells. Using microarray analysis, we identified 71 miRNAs exhibiting greater than 2-fold expression changes in resveratrol-treated cells relative to their expression levels in untreated cells. Furthermore, we identified target genes related to apoptosis, cell cycle regulation, cell proliferation, and differentiation using a miRNA target-prediction program. In conclusion, our data demonstrate that resveratrol induces considerable changes in the miRNA expression profiles of A549 cells, suggesting a novel approach for studying the anticancer mechanisms of resveratrol.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94526
DOI
10.1007/s10059-011-1037-z
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://dx.doi.org/10.1007/s10059-011-1037-z
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