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Immunohistochemical analysis of claudin expression in pancreatic cystic tumors

Authors
 Jin Ha Lee  ;  Kyung Sik Kim  ;  Tae-Jung Kim  ;  Sung Pil Hong  ;  Si Young Song  ;  Jae Bock Chung  ;  Seung Woo Park 
Citation
 ONCOLOGY REPORTS, Vol.25(4) : 971-978, 2011 
Journal Title
ONCOLOGY REPORTS
ISSN
 1021-335X 
Issue Date
2011
MeSH
Adenocarcinoma, Mucinous/metabolism* ; Adenocarcinoma, Mucinous/pathology ; Adenoma/metabolism ; Adenoma/pathology ; Carcinoma, Pancreatic Ductal/metabolism* ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Papillary/metabolism* ; Carcinoma, Papillary/pathology ; Claudin-4 ; Claudins ; Female ; Humans ; Immunoenzyme Techniques ; Male ; Membrane Proteins/metabolism* ; Middle Aged ; Neoplasm Staging ; Pancreatic Neoplasms/metabolism* ; Pancreatic Neoplasms/pathology ; Prognosis ; Survival Rate
Abstract
Aberrant expression of the claudin family of proteins has been reported in many human cancers, including pancreatic ductal carcinoma. Intraductal papillary mucinous neoplasms of the pancreas (IPMN) and mucinous cystic neoplasms (MCN) are considered precancerous lesions that are able to progress towards pancreatic ductal adenocarcinoma. We analyzed the expression of several claudin family members using surgical IPMN and MCN specimens to clarify the relationships between claudin expression and clinicopathological features. Twenty-nine and 25 consecutive cases of IPMN and MCN were selected and the expression of claudin-2, -4 and -18 was analyzed by immunohistochemistry. In addition, IPMN and MCN histological grade as well as IPMN subtypes were analyzed in relation to claudin expression. The 29 cases of IPMN comprised of 3 (10.3%) adenomas, 18 (62.1%) borderline malignancies and 8 (27.6%) carcinomas. The 25 cases of MCN comprised of 13 (52%) adenomas, 5 (20%) borderline malignancies and 7 (28%) carcinomas. Claudin-2, -4 and -18 showed strong expression both in IPMN and MCN, with the exception of claudin-4 in MCN. The expression grades of claudin-2 in both IPMN and MCN became weaker with increased histological grade. On the other hand, the expression grades of claudin-4 and -18 became stronger with increased histological grade in both IPMN and MCN. With regard to histological subtype, claudin-4 expression was the strongest in pancreatobiliary type IPMN, and claudin-18 expression was the strongest in gastric type IPMN. The distinct expression patterns of claudin-2, -4 and -18 suggest that claudins may serve as useful molecular markers for tumor differentiation and progression in IPMN and MCN.
Full Text
http://www.spandidos-publications.com/or/25/4/971
DOI
10.3892/or.2011.1132
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Jae Bock(정재복)
Hong, Sung Pil(홍성필)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94524
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