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Analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study

Title
Analgesic mechanism of electroacupuncture in an arthritic pain model of rats: a neurotransmitter study
Authors
Young-Chul Yoo;Jin Hwan Oh;Sun Joon Bai;Yeong Kyu Lee;Tae Dong Kwon
Issue Date
2011
Journal Title
Yonsei Medical Journal
ISSN
0513-5796
Citation
Yonsei Medical Journal, Vol.52(6) : 1016~1021, 2011
Abstract
PURPOSE: We investigated what kinds of neurotransmitters are related with electroacupuncture (EA) analgesia in an arthritic pain model of rats. MATERIALS AND METHODS: One hundred rats were assigned to six groups: control, EA, opioid, adrenergic, serotonin and dopamine group. A standardized model of inflammatory arthritis was produced by injecting 2% carrageenan into the knee joint cavity. EA was applied to an acupoint for 30 min in all groups except fo the control group. In the opioid, adrenergic, serotonin and dopamine groups, each receptor antagonist was injected intraperitoneally to their respective group before initiating EA. RESULTS: In the opioid receptor antagonist group, adrenergic receptor antagonist group, serotonin receptor antagonist group, dopamine receptor antagonist group and the control group weight-bearing force decreased significantly from 30 min to 180 min after EA in comparison with the EA group. CONCLUSION: The analgesic effects of EA are related to opioid, adrenergic, serotonin and dopamine receptors in an arthritic pain model of rats.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94509
DOI
10.3349/ymj.2011.52.6.1016
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
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