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Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling

Title
Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling
Authors
Ji-Hwan Ryu;Seung Chul Shin;Won-Jae Lee;Joo-Heon Yoon;Kyung-Ah Lee;Aeri C. Kim;Boram Kim;Hyejin You;Sung-Hee Kim
Issue Date
2011
Journal Title
Science
ISSN
0036-8075
Citation
Science, Vol.334(6056) : 670~674, 2011
Abstract
The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone-dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94449
DOI
10.1126/science.1212782
Appears in Collections:
1. 연구논문 > 5. Research Institutes > 생체방어연구센터
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
Yonsei Authors
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