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MyD88-dependent Toll-like receptor signaling is required for murine macrophages response to IS2

Title
 MyD88-dependent Toll-like receptor signaling is required for murine macrophages response to IS2 
Authors
 Hua Li ; Wan-Jae Kim ; Kwang-Ho Lee ; Dong-Kug Choi ; Pyo-Jam Park ; Sushruta Koppula ; Tae-Bong Kang ; Ji-Hwan Ryu ; Sang-Kyu Ye ; Tack-Joong Kim ; Eun-Yi Moon ; Hyung-Sun Youn ; Seung-Hwan Lee ; Jun Jiang 
Issue Date
2011
Journal Title
 International Immunopharmacology 
ISSN
 1567-5769 
Citation
 International Immunopharmacology, Vol.11(10) : 1578~1583, 2011 
Abstract
IS2, a soluble β-glucan isolated from the cell wall of mutated Saccharomyces cerevisiae (S. cerevisiae) enhances the immune response compared to the wild type (WT) β-glucan. In the present investigation we report that Toll-like receptor (TLR)/MyD88 signaling pathway was responsible in IS2 β-glucan-mediated cellular response in RAW264.7 murine macrophages. Data revealed that IS2 β-glucan significantly up-regulated the TLR2/TLR4 expression. Moreover, TLR2/TLR4 responds to IS2 resulting in murine macrophage activation. In addition, the IS2 signal led to cytokine secretions of IL-6 and TNF-α. In the case of thioglycolate-elicited peritoneal macrophages from MyD88-deficient mice, the decrease in cytokines was observed. Further the mitogen-activated protein kinases (MAPKs) phosphorylation was evident and degradation of IκB-α was increased after stimulation with IS2 β-glucan. Further examination with MyD88-deficient mice revealed that the MyD88 pathway might play an important role for IS2 β-glucan-mediated activation of macrophages.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94430
DOI
10.1016/j.intimp.2011.05.017
Appears in Collections:
1. 연구논문 > 5. Research Institutes > 생체방어연구센터
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1567576911002281
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