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Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography

Title
 Localization of ictal onset zones in Lennox-Gastaut syndrome using directional connectivity analysis of intracranial electroencephalography 
Authors
 Young-Jin Jung ; Hoon-Chul Kang ; Heung Dong Kim ; Chang-Hwan Im ; Shin-Hye Kim ; Jae-Hyun Cho ; Dong-Seok Kim ; Joon Soo Lee ; Keom-Ok Choi 
Issue Date
2011
Journal Title
 Seizure - European Journal of Epilepsy 
ISSN
 1059-1311 
Citation
 Seizure - European Journal of Epilepsy, Vol.20(6) : 449~457, 2011 
Abstract
INTRODUCTION: Neuroscientists are becoming interested in the application of computational EEG analysis to the identification of ictal onset zones; however, most studies have focused on the localization of ictal onset zones in focal epilepsy. The present study aimed to estimate the ictal onset zone of Lennox-Gastaut syndrome (LGS) with bilaterally synchronous epileptiform discharges from intracranial electroencephalography (iEEG) recordings using directional connectivity analysis. METHODS: We analyzed ictal iEEG data acquired from three LGS patients who underwent epileptic surgery with favorable surgical outcomes. To identify the ictal onset zones, we estimated the functional directional connectivity network among the intracerebral electrodes using the directed transfer function (DTF) method. RESULTS: The analysis results demonstrated that areas with high average outflow values corresponded well with the surgical resection areas identified using electrophysiologic data and conventional neuroimaging modalities. DISCUSSIONS: Our results suggest that the DTF analysis can be a useful auxiliary tool for determining surgical resection areas prior to epilepsy surgery in LGS patients. This is the first research article demonstrating that directional connectivity analysis of iEEG recording data can be used for delineating surgical resection areas in generalized epilepsy patients who need surgical treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94423
DOI
10.1016/j.seizure.2011.02.004
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1059131111000483
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