Optimal sedative dose of propofol to start MRI in children with cerebral palsy.
Eun Jung Kim ; Youn Yi Jo ; Hae Keum Kil
Korean Journal of Anesthesiology, Vol.61(3) : 216~219, 2011
Korean Journal of Anesthesiology
BACKGROUND: This study was designed to determine the optimal sedative dose of propofol to start brain magnetic resonance imaging (MRI) in children with cerebral palsy (CP).
METHODS: Twenty children, aged 0.5-5 years, were administered propofol to achieve a University of Michigan Sedation Scale (UMSS) score ≥ 3 in the MRI room. The proper dose of propofol was determined using the up-and-down method.
RESULTS: The ED50 and ED95 for successful sedation with a UMSS ≥ 3 were 2.07 mg/kg (95% CI 1.69-2.56) and 2.69 mg/kg (95% CI 2.35-5.59). Respiratory events occurred in 5 patients and were resolved with neck extension, chin lift, or transient respiratory assistance with successful sedation.
CONCLUSIONS: Low dose propofol can safely facilitate the initiation of MRI in children with CP