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3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier.

Authors
 Hye Jung Baik ; Nam Muk Oh ; Eun Seong Lee ; Yu Seok Youn ; Kyung Taek Oh ; So Young Park ; Na Young Yoo ; Young Taik Oh 
Citation
 Colloids and Surfaces B-Biointerfaces, Vol.84(2) : 585~590, 2011 
Journal Title
 Colloids and Surfaces B-Biointerfaces 
ISSN
 0927-7765 
Issue Date
2011
Abstract
Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaluate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94371
DOI
10.1016/j.colsurfb.2011.01.017
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0927776511000373
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