3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier.
Hye Jung Baik ; Nam Muk Oh ; Eun Seong Lee ; Yu Seok Youn ; Kyung Taek Oh ; So Young Park ; Na Young Yoo ; Young Taik Oh
Colloids and Surfaces B-Biointerfaces, Vol.84(2) : 585~590, 2011
Colloids and Surfaces B-Biointerfaces
Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaluate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins.