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Antioxidant encapsulated porous poly(lactide-co-glycolide) microparticles for developing long acting inhalation system

Authors
 Na Young Yoo ; Yu Seok Youn ; Eun Seong Lee ; Young Taik Oh ; Kyung-Hoi Cha ; Deok-Keun Lee ; Kyung Taek Oh ; Nam Muk Oh 
Citation
 Colloids and Surfaces B-Biointerfaces, Vol.88(1) : 419~424, 2011 
Journal Title
 Colloids and Surfaces B-Biointerfaces 
ISSN
 0927-7765 
Issue Date
2011
Abstract
The purpose of this study was to fabricate porous poly(lactide-co-glycolide) (PLGA) microparticles for efficient pulmonary deposition and increased therapeutic duration of the antioxidant anthocyanin (ATH). These microparticles were prepared by a water-in-oil-in-water (W(1)/O/W(2)) multi-emulsion method with vaporizing ammonium bicarbonate (AB) as a porogen and starch as a viscous additive. High porosity achieved by the decomposition reaction of AB to the base of ammonia, carbon dioxide, and water vapor at 50°C enabled efficient deposition of ATH throughout the entire lung in BALB/c mice. In addition, the porous microparticles incorporating starch showed sustained ATH release characteristics (up to 5 days) and protracted antioxidant activity (up to 5 days) for 2,2-diphenyl-1-pikryl-hydrazyl (DPPH) radicals, which was comparable to that of the porous microparticles without starch which completely released ATH in 2h. Furthermore, these porous microparticles incorporating starch led to longer ATH residence (up to 20 days) in in vivo lung epithelium. We believe that this system has great pharmaceutical potential as a long-acting antioxidant for continuously relieving oxidative stress in pulmonary diseases like chronic obstructive pulmonary disease (COPD).
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94335
DOI
10.1016/j.colsurfb.2011.07.024
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0927776511004279
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