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Changes in cell-mediated immune response after lung resection surgery for MDR-TB patients

Authors
 Seung-Kyu Park ; Sunghee Hong ; Sang-Nae Cho ; Sungae Cho ; Jang Eun Cho ; Donk Ok Shin ; In Hee Lee ; Seok-Yong Eum 
Citation
 Tuberculosis, Vol.91(4) : 300~307, 2011 
Journal Title
 Tuberculosis 
ISSN
 1472-9792 
Issue Date
2011
Abstract
The immune responses of multidrug-resistant tuberculosis (MDR-TB) patients undergoing lung resection surgery were investigated in order to understand the mechanism of strong immune suppression in MDR-TB. We examined changes in cell-mediated immune response (CMI) of a total of sixteen MDR-TB patients, three of them extensively drug-resistant tuberculosis (XDR-TB) patients, after the removal of the heavily diseased lung section. The IFN-γ response to Mycobacterium tuberculosis culture filtrate proteins (Mtb-CFP), one of the most important CMI to defend TB, showed a statistically significant elevation in 2-4 months after operation when compared to the preoperative CMI in patients who were converted into AFB negative and cured in two years' follow-up, suggesting that the recovery of CMI may be one of the key factors in the successful treatment of MDR-TB. Interestingly, IL-10 response to Mtb-CFP was also elevated in 2-4 months after surgery in cured patients although both proliferative response and PBMC composition were not significantly changed. Infection with first- or second-line drugs resistant Mtb reduces the efficiency of chemotherapeutic treatment of MDR-TB to about 50%. Thus, this study suggests that chemotherapeutic treatment of MDR-TB may be more effective when combined with accompanying therapy that increases CMI, includes lung resection surgery.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94315
DOI
10.1016/j.tube.2011.02.003
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
1. 연구논문 > 1. College of Medicine > Medical Research Center
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1472979211000266
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