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Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on Asian diagnostic criteria

Title
Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on Asian diagnostic criteria
Authors
Terumi Kamisawa;Myung-Hwan Kim;Gourdas Choudhuri;Tsung-Chun Lee;Hsiu-Po Wang;Kyu Taek Lee;Jae Bock Chung;Tooru Shimosegawa;Kazuichi Okazaki;Vallath Balakrishnan;Quanda Liu;Wei-Chih Liao
Issue Date
2011
Journal Title
Pancreas
ISSN
0885-3177
Citation
Pancreas, Vol.40(2) : 200~205, 2011
Abstract
OBJECTIVES: To clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) in Asia. METHODS: A retrospective, actual situation survey of AIP diagnosed by Asian criteria was conducted in 10 centers of Japan, Korea, Taiwan, China, and India. RESULTS: A total of 327 AIP cases (258 male and 69 female subjects; average age, 60.0 years) were enrolled. Obstructive jaundice was the most frequent initial symptom (46%-74%), followed by weight loss (4%-51%) and abdominal pain (19%-44%). Diffuse swelling of the pancreas was frequent in Japan (64%) and Korea (81%), but segmental swelling of the pancreas was more frequent in Taiwan (70%) and China (72%) (P < 0.01). Serum immunoglobulin G4 levels were elevated in 58%-100% of cases in Japan, Korea, and Taiwan. Pathologically, almost all AIPs in Asia were lymphoplasmacytic sclerosing pancreatitis. Sclerosing cholangitis was the most frequent extrapancreatic lesion (60%-81%). Steroid therapy was a major and effective therapeutic strategy in Japan, Korea, and Taiwan. However, the rate of resection or bypass operation was higher in Taiwan (40%) and China (72%) (P < 0.01). CONCLUSIONS: Features of AIP are fundamentally similar in Japan, Korea, Taiwan, and China. Knowledge of emerging AIP should be more widespread in Asia to avoid unnecessary operation.
URI
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201103000-00005&LSLINK=80&D=ovft

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94312
DOI
10.1097/MPA.0b013e3181fab696
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
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