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Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on Asian diagnostic criteria

Authors
 Terumi Kamisawa  ;  Myung-Hwan Kim  ;  Wei-Chih Liao  ;  Quanda Liu  ;  Vallath Balakrishnan  ;  Kazuichi Okazaki  ;  Tooru Shimosegawa  ;  Jae Bock Chung  ;  Kyu Taek Lee  ;  Hsiu-Po Wang  ;  Tsung-Chun Lee  ;  Gourdas Choudhuri 
Citation
 PANCREAS, Vol.40(2) : 200-205, 2011 
Journal Title
PANCREAS
ISSN
 0885-3177 
Issue Date
2011
MeSH
Asia/epidemiology ; AsianContinental Ancestry Group* ; Autoantibodies/blood ; AutoimmuneDiseases/diagnosis* ; AutoimmuneDiseases/ethnology ; AutoimmuneDiseases/physiopathology ; AutoimmuneDiseases/therapy ; Biomarkers/blood ; Biopsy ; Female ; Health Status Indicators* ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Pancreatectomy ; Pancreatitis/diagnosis* ; Pancreatitis/ethnology ; Predictive Value of Tests ; Retrospective Studies ; Steroids/therapeutic use ; Tomography, X-Ray Computed ; Treatment Outcome
Keywords
autoimmune pancreatitis ; IgG4 ; Asia
Abstract
OBJECTIVES: To clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) in Asia.

METHODS: A retrospective, actual situation survey of AIP diagnosed by Asian criteria was conducted in 10 centers of Japan, Korea, Taiwan, China, and India.

RESULTS: A total of 327 AIP cases (258 male and 69 female subjects; average age, 60.0 years) were enrolled. Obstructive jaundice was the most frequent initial symptom (46%-74%), followed by weight loss (4%-51%) and abdominal pain (19%-44%). Diffuse swelling of the pancreas was frequent in Japan (64%) and Korea (81%), but segmental swelling of the pancreas was more frequent in Taiwan (70%) and China (72%) (P < 0.01). Serum immunoglobulin G4 levels were elevated in 58%-100% of cases in Japan, Korea, and Taiwan. Pathologically, almost all AIPs in Asia were lymphoplasmacytic sclerosing pancreatitis. Sclerosing cholangitis was the most frequent extrapancreatic lesion (60%-81%). Steroid therapy was a major and effective therapeutic strategy in Japan, Korea, and Taiwan. However, the rate of resection or bypass operation was higher in Taiwan (40%) and China (72%) (P < 0.01).

CONCLUSIONS: Features of AIP are fundamentally similar in Japan, Korea, Taiwan, and China. Knowledge of emerging AIP should be more widespread in Asia to avoid unnecessary operation.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201103000-00005&LSLINK=80&D=ovft
DOI
10.1097/MPA.0b013e3181fab696
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chung, Jae Bock(정재복)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94312
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