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Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture

Title
Coenzyme Q10 protects neurons against neurotoxicity in hippocampal slice culture
Authors
Ran Won;Kyung Hee Lee;Bae Hwan Lee
Issue Date
2011
Journal Title
Neuroreport
ISSN
0959-4965
Citation
Neuroreport, Vol.22(14) : 721~726, 2011
Abstract
This study investigated the neuroprotective effects of coenzyme Q10 (CoQ10) against oxidative stress induced by kainic acid (KA) in organotypic hippocampal slice culture of rats. Cultured slices were injured by exposure to 5 µM of KA for 18 h and then treated with different concentrations of CoQ10. Neuronal cell death measured as propidium iodide uptake was reduced at 24 h after treatment with 1 µM of CoQ10. We also observed an increased number of surviving CA3 neurons in 0.1 and 1 µM concentrations of CoQ10-treated groups using cresyl violet staining. CoQ10 (0.01, 0.1, and 1 µM) treatment significantly decreased the 2',7'-dichlorofluorescein fluorescence and the expression of NQO1 in the CoQ10-treated groups was significantly lower than that in the KA-only group. These results suggest that CoQ10 may protect hippocampal neurons against oxidative stress
URI
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201110050-00011&LSLINK=80&D=ovft

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94299
DOI
10.1097/WNR.0b013e32834acb8d
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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