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Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro

Authors
 Eun Jung Bak ; Hong Gyu Park ; Jeong-Heon Cha ; Yun-Jung Yoo ; Younghwa Na ; Gye-Hyeong Woo ; Tong-Il Lee ; ChoongHwan Lee 
Citation
 BMB Reports, Vol.44(6) : 410~414, 2011 
Journal Title
 BMB Reports 
ISSN
 1976-6696 
Issue Date
2011
Abstract
Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94222
DOI
10.5483/BMBRep.2011.44.6.410
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
1. 연구논문 > 5. Research Institutes > Oral Cancer Research Institute
Yonsei Authors
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