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Hypoxia-induced expression of VEGF in the organotypic spinal cord slice culture

Authors
 안성수 ; 오진수 ; 윤도흠 ; 하윤 ; 곽소정 ; 김긍년 ; 김효진 
Citation
 Neuroreport, Vol.22(2) : 55~60, 2011 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2011
Abstract
We used the erythropoietin enhancer and Simian virus-40 promoter to create a hypoxia-inducible gene expression system to investigate the effect of vascular endothelial growth factor (VEGF) gene therapy on neuroprotection and neurogenesis in organotypic spinal cord slice culture. The organotypic spinal cord slice culture transfected with pEpo-SV-VEGF expressed the highest amount of VEGF under hypoxic conditions and showed decreased apoptosis and increased proliferation, and evidence of neurogenesis. Our results show that the hypoxia-induced VEGF expression in an organotypic spinal cord slice culture may lead to an optimal treatment for spinal cord injury.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94171
DOI
10.1097/WNR.0b013e3283418b00
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
1. 연구논문 > 1. College of Medicine > Medical Research Center
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
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Link
 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-201101260-00002&LSLINK=80&D=ovft
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