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Isolation of a Klebsiella pneumoniae isolate of sequence type 258 producing KPC-2 carbapenemase in Korea

Authors
 Kyoung Ho Roh  ;  Chang Kyu Lee  ;  Jang Wook Sohn  ;  Wonkeun Song  ;  Dongeun Yong  ;  Kyungwon Lee 
Citation
 KOREAN JOURNAL OF LABORATORY MEDICINE , Vol.31(4) : 298-301, 2011 
Journal Title
KOREAN JOURNAL OF LABORATORY MEDICINE
ISSN
 1598-6535 
Issue Date
2011
MeSH
Aged ; Bacterial Proteins/antagonists & inhibitors ; Bacterial Proteins/metabolism ; Carbapenems/pharmacology ; Drug Resistance, Bacterial/genetics ; Female ; Humans ; Klebsiellapneumoniae/drug effects ; Klebsiellapneumoniae/genetics ; Klebsiellapneumoniae/isolation& purification* ; Microbial Sensitivity Tests ; Republic ofKorea ; SequenceAnalysis, DNA ; Urinary Tract Infections/diagnosis* ; Urinary Tract Infections/microbiology ; beta-Lactamase Inhibitors ; beta-Lactamases/biosynthesis ; beta-Lactamases/genetics* ; beta-Lactamases/metabolism
Keywords
KPC-2 ; Klebsiellapneumoniae ; ST258
Abstract
Carbapenem-resistant Klebsiella pneumoniae isolates producing K. pneumoniae carbapenemases (KPC) were first reported in the USA in 2001, and since then, this infection has been reported in Europe, Israel, South America, and China. In Korea, the first KPC-2-producing K. pneumoniae sequence type (ST) 11 strain was detected in 2010. We report the case of a patient with a urinary tract infection caused by KPC-2-producing K. pneumoniae. This is the second report of a KPC-2-producing K. pneumoniae infection in Korea, but the multilocus sequence type was ST258. The KPC-2-producing isolate was resistant to all tested β-lactams (including imipenem and meropenem), amikacin, tobramycin, ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole, but was susceptible to gentamicin, colistin, polymyxin B, and tigecycline. The KPC-2-producing isolate was negative to phenotypic extended-spectrum β-lactamase (ESBL) and AmpC detection tests and positive to modified Hodge test and carbapenemase inhibition test with aminophenylboronic acid.
Files in This Item:
T201103294.pdf Download
DOI
10.3343/kjlm.2011.31.4.298
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/94150
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