Cited 11 times in

Metallo-beta-lactamase production by Pseudomonas otitidis: a species-related trait.

Authors
 Maria Cristina Thaller ; Luisa Borgianni ; Gian Maria Rossolini ; David Stroman ; Joseph Dajcs ; Kyungwon Lee ; Yunsop Chong ; Gustavo Di Lallo 
Citation
 Antimicrobial Agents and Chemotherapy, Vol.55(1) : 118~123, 2011 
Journal Title
 Antimicrobial Agents and Chemotherapy 
ISSN
 0066-4804 
Issue Date
2011
Abstract
Susceptibility to several β-lactams and β-lactamase production was investigated in a collection of 20 strains of Pseudomonas otitidis, a new Pseudomonas species that has been recently recognized in association with otic infections in humans. All strains appeared to be susceptible to piperacillin, cefotaxime, ceftazidime, and aztreonam, while resistance or decreased susceptibility to carbapenems was occasionally observed. All strains were found to express metallo-β-lactamase (MBL) activity and to carry a new subclass B3 MBL gene, named bla(POM), that appeared to be highly conserved in this species. P. otitidis, therefore, is the first example of a pathogenic Pseudomonas species endowed with a resident MBL. The POM-1 protein from P. otitidis type strain MCC10330 exhibits the closest similarity (60 to 64%) to the L1 MBL of Stenotrophomonas maltophilia. Expression in Escherichia coli and Pseudomonas aeruginosa revealed that, similar to L1 and other subclass B3 MBLs, POM-1 confers decreased susceptibility or resistance to carbapenems, penicillins, and cephalosporins but not to aztreonam. Expression of the POM MBL in P. otitidis is apparently constitutive and, in most strains, does not confer a carbapenem-resistant phenotype. However, a strong inoculum size effect was observed for carbapenem MICs, and carbapenem-resistant mutants could be readily selected upon exposure to imipenem, suggesting that carbapenem-based regimens should be considered with caution for P. otitidis infections.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94137
DOI
10.1128/AAC.01062-10
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201103282.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse