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Neurotrophin-3-Over-Expressing Mesenchymal Stem Cell Transplantation Improves Functional Recovery and Axonal Outgrowth in a Rat Model of Spinal Cord Injury

Title
 Neurotrophin-3-Over-Expressing Mesenchymal Stem Cell Transplantation Improves Functional Recovery and Axonal Outgrowth in a Rat Model of Spinal Cord Injury
Authors
 Kyung Hee Lee; Jin soo Oh; Keung Nyun Kim; Do Heum Yoon; William A. Pennant; Bae Hwan Lee; Yoon Ha
Issue Date
2011
Journal Title
 Tissue Engineering and Regenerative Medicine
ISSN
 1738-2696
Citation
 Tissue Engineering and Regenerative Medicine, Vol.8(5) : 477~481, 2011
Abstract
We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94116
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
1. 연구논문 > 1. College of Medicine > Dept. of Neurosurgery
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
Yonsei Authors
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