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Hepatocellular carcinoma during pregnancy: is hepatocellular carcinoma more aggressive in pregnant patients?

Authors
 Kang Kook Choi ; Young Ju Hong ; Kyung Sik Kim ; Woo Jung Lee ; Jin Sub Choi ; Young Nyun Park ; Sae Byeol Choi 
Citation
 Journal of Hepato-Biliary-Pancreatic Sciences, Vol.18(3) : 422~431, 2011 
Journal Title
 Journal of Hepato-Biliary-Pancreatic Sciences 
ISSN
 1868-6974 
Issue Date
2011
Abstract
BACKGROUND/PURPOSE: Hepatocellular carcinoma (HCC) during pregnancy is a very rare condition and is believed to have a worse prognosis than HCC in non-pregnant women. We evaluated the prognosis and the diagnostic and therapeutic strategies for HCC in pregnant women. METHODS: We retrospectively analyzed 4 cases in our hospital and 44 cases described in the medical literature since 1957; we also compared the cases reported before 1995 and those reported during/after 1995. RESULTS: The overall 6-month and 1-, 2-, and 3-year survival rates in the patients reported in the literature were 50, 29.5, 18.2, and 13.6%, respectively (n = 44). The mean ages at diagnosis before and during/after 1995 were 31.4 ± 7.2 and 28.9 ± 4.4 years, respectively (P = 0.113). The following characteristics were significantly more common in the later group: fewer pregnancies; the absence of advanced signs or symptoms; receipt of therapy; tendency to undergo surgery; and higher 6-month and 1-, 2-, and 3-year survival rates. The median survivals of the groups before and during/after 1995 were 18 and 25.5 months, respectively (P < 0.001). CONCLUSIONS: The morbidity and mortality of HCC during pregnancy has improved over time, as diagnoses have tended to be made earlier and patients have tended to receive surgical and other treatments.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94113
DOI
10.1007/s00534-010-0345-6
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
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Link
 http://link.springer.com/article/10.1007%2Fs00534-010-0345-6
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