Cited 21 times in

Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR

Title
Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR
Authors
Jinho Yu;Mi-Jin Kang;Soo-Jong Hong MD, PhD;Yee-Jin Shin MD, PhD;Won-Ah Choi MS;Young-Hwa Song MD;Ji-Won Kwon MD;Byoung-Ju Kim
Issue Date
2011
Journal Title
Pediatric Pulmonology
ISSN
8755-6863
Citation
Pediatric Pulmonology, Vol.46(7) : 701~708, 2011
Abstract
The gasdermin A (GSDMA) and gasdermin B (GSDMB) genes are located at 17q21.2. The GSDM family genes have been studied in the gastrointestinal tract but recent reports suggest that GSDMB is associated with childhood asthma in several populations. We investigated the association of the GSDMA and GSDMB variants with asthma in Korean children, and to assess the effect of these variants on intermediate phenotypes of asthma. Asthmatic (n = 778) and normal (n = 522) children were enrolled and genotypes were determined using PCR-RFLP. Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389). And a combination of risk alleles of two polymorphisms was associated with asthma susceptibility and a frequency of those was higher in asthmatic children with increased levels of total IgE (aOR 1.77, 95% CI 1.15-2.72) and BHR (aOR 1.54, 95% CI 0.99-2.40) compared to normal. Also, we observed a significant association between haplotype of two polymorphisms and asthma susceptibility. The region including the GSDMA and GSDMB polymorphisms may be associated with asthma susceptibility and intermediate phenotypes of asthma, such as elevated IgE and BHR, in Korean children with asthma. These results strongly support an important role for the GSDMA and GSDMB in the development of childhood asthma.
URI
http://onlinelibrary.wiley.com/doi/10.1002/ppul.21424/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94088
DOI
10.1002/ppul.21424
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Psychiatry
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse