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The analysis of tumorigenicity data using a frailty effect

Authors
 김윤남 ; 남정모 ; 최은희 
Citation
 Journal of the Korean Statistical Society, Vol.40(3) : 281~290, 2011 
Journal Title
 Journal of the Korean Statistical Society 
ISSN
 1226-3192 
Issue Date
2011
Abstract
In animal tumorigenicity data, the time of occurrence of the tumor is not observed because the existence of the tumor is looked for only at either the time of death or the time of sacrifice of the animal. Such an incomplete data structure makes it difficult to investigate the impact of treatment on the occurrence of tumors. A three-state model (no tumor–tumor–death) is used to model events that occurred sequentially and to connect them. In this paper, we also employed a frailty effect to model the dependency of death on tumor occurrence. For the inference of parameters, an EM algorithm is considered. The method is applied to a real bladder tumor data set and a simulation study is performed to show the behavior of the proposed estimators
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/94029
DOI
10.1016/j.jkss.2010.20.007
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biostatistics
1. 연구논문 > 1. College of Medicine > Dept. of Preventive Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S1226319210000980
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