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The effect of anemia and left ventricular geometric patterns on renal disease progression in type 2 diabetic nephropathy.

Title
The effect of anemia and left ventricular geometric patterns on renal disease progression in type 2 diabetic nephropathy.
Authors
Sung Jin Moon;Ki Sun Bae;Sung Kyu Ha;Se Joong Rim,;Jung Eun Lee;Jung Tak Park;Jwa Kyung Kim;Hyeong Cheon Park
Issue Date
2011
Journal Title
Journal of Nephrology
ISSN
1121-8428
Citation
Journal of Nephrology, Vol.24(1) : 50~59, 2011
Abstract
BACKGROUND: Left ventricular (LV) geometric patterns have never been evaluated as independent risk factors for renal disease progression (RDP). We investigated the risk factors for RDP in type 2 diabetic nephropathy patients, especially focusing on the effects of LV geometric patterns. METHODS: This was a single-center retrospective cohort study. Type 2 diabetic nephropathy patients who underwent echocardiography for routine checkup were recruited. Baseline laboratory data within 1 month from the time of echocardiography and clinical and follow-up laboratory data were collected by retrospective reviews. RESULTS: A total of 150 patients (90 men, mean age 62.9 years) were enrolled. Distributions of the patients according to LV geometric patterns were as follows: normal 21 (14.0%), concentric remodeling 18 (12.0%), concentric hypertrophy 70 (46.7%) and eccentric hypertrophy 41 (27.3%). During the study period (30.1 ± 19.4 months), RDP developed in 53 of 150 patients (35.3%). On univariate analysis, use of erythropoiesis-stimulating agent, hemoglobin, serum creatinine, estimated glomerular filtration rate (eGFR), serum albumin, log-transformed 24-hour urine protein, LV mass index and eccentric hypertrophy were strong predictors of renal outcomes. RDP-free survival was significantly decreased in the eccentric hypertrophy group (p=0.001, vs. other groups) according to Kaplan-Meier analysis. On multivariate analysis, eGFR, eccentric hypertrophy and hemoglobin levels were significant predictors of renal outcome. CONCLUSION: Anemia and eccentric hypertrophy may be considered as important risk factors for RDP. Multicenter prospective trials should be needed to validate the effect of LV geometric patterns on RDP.
URI
http://www.jnephrol.com/article/the-effect-of-anemia-and-left-ventricular-geometric-patterns-on-renal-disease-progression-in-type-2-diabetic-nephropathy-jnephrol-09-00159

http://ir.ymlib.yonsei.ac.kr/handle/22282913/94021
DOI
10.5301/JN.2010.353
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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